PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury (PROTEST)

Exclusion Criteria14

• i) Known Hypersensitivity to FRAGMIN (Dalteparin), or its constituents including benzyl alcohol or to other low molecular weight heparins and/or heparins or pork products
• ii) Known history of confirmed or suspected immunologically-mediated heparin-induced thrombocytopenia (delayed-onset severe thrombocytopenia), and/or in patients with a known history of a positive in vitro platelet-aggregation test in the presence of FRAGMIN (Dalteparin) is positive
• iii) Known septic endocarditis
• iv) Uncontrollable active bleeding
• v) Known major blood clotting disorders
• vi) Known acute gastroduodenal ulcer (with active bleeding)
• vii) Severe uncontrolled hypertension (i.e. BP>210 despite medications)
• viii) Known diabetic or hemorrhagic retinopathy
• ix) Anticipated to be unable to receive SCD on at least one lower extremity due to nature of injuries for duration of intervention period
• x) Presence of another confounding factor that can adequately explain the poor GCS at time of presentation (e.g. drug toxicity, seizure)
• xi) Known presence of irreversible coagulopathies
• xii) Known Pregnancy
• xiii) Participants extremely low weight (<45 kg), or extremely high weight (>120kg)
• xiv) Not expected to survive more than 48 hours from admission