RecruitingNot ApplicableNCT06544408

Rapid Treatment of PTSD With Accelerated Non-Invasive Brain Stimulation

Sponsor

Florida State University

Enrollment

132 participants

Start Date

Nov 6, 2024

Study Type

INTERVENTIONAL

Conditions

Traumatic Brain Injury Post Traumatic Stress Disorder

Summary

This study will test the clinical efficacy of an accelerated TMS (accel-TMS) protocol that rapidly addresses PTSD symptoms with 1 week (25 sessions over 5 days) of condensed treatment.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing an accelerated form of non-invasive brain stimulation — delivered over just a few days rather than weeks — to treat PTSD (post-traumatic stress disorder). **You may be eligible if...** - You are 18–65 years old and meet the diagnostic criteria for PTSD - Your PTSD symptom score is above 33 on the PCL-5 questionnaire - Your medications (if any) and therapy regimen have been stable for at least one month prior to the study **You may NOT be eligible if...** - You have a medical reason that prevents brain stimulation, such as metal in the head, a seizure disorder, brain tumor, stroke, aneurysm, or multiple sclerosis - You have had a substance use disorder in the last 3 months - You are currently at significant risk due to substance use Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICECool B70 AP Coil - Active (dl-PFC)

One side of the coil is the active and the other is sham. The B70 AP coil will be positioned over the left dorsolateral prefrontal cortex (dl-PFC).

DEVICECool B70 AP Coil- Sham (dl-PFC)

One side of the coil is the active and the other is sham. The B70 AP coil will be positioned over the left dorsolateral prefrontal cortex (dl-PFC).

DEVICECool D-B80 AP Coil - Active (dm-PFC)

One side of the coil is the active and the other is sham. The cool D-B80 AP coil will be positioned over the midline (bilateral) dorsal medial prefrontal cortex (dmPFC) using location 25.8% distance from nasion to inion.

DEVICECool D-B80 AP Coil - Sham (dm-PFC)

DEVICECool B70 Treatment Coil - Active Only

The treatment will be the same as the left dl-PFC accel-TMS dl-PFC except that the Cool B70 Treatment coil only has an active treatment coil.

Locations(1)

Florida State University

Tallahassee, Florida, United States

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NCT06544408

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