RecruitingPhase 2NCT03572660

Use of Bone Marrow Derived Stem Cell and G-CSF With Circulatory Assistance in the Treatment of DCM

Phase II Study Assessing the Combined Use of Autologous Bone Marrow Derived Mononuclear Cells and G-csf With Percutaneous Circulatory Assistance in the Treatment of Dilated Cardiomyopathy

Sponsor

Barts & The London NHS Trust

Enrollment

20 participants

Start Date

Dec 24, 2018

Study Type

INTERVENTIONAL

Conditions

Dilated Cardiomyopathy

Summary

DCM Support is recruiting patients with dilated cardiomyopathy and heart failure symptoms. The goal of this clinical trial is to examine whether treatment with a patient's own stem cells can improve their heart function and alleviate heart failure symptoms. * Stem cells will be collected from bone marrow in the patient's hip under local anaesthetic. * The stem cells will be infused into the arteries that supply blood to the heart under local anaesthetic. * A mini heart pump will be used to take the strain off the heart during the procedure. * The follow-up involves a phone call at 1 month and clinic visits at 3 and 12 months

Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether injecting stem cells from a patient's own bone marrow — combined with a growth factor drug called G-CSF and a heart-assist device — can improve heart function in patients with a seriously weakened heart (dilated cardiomyopathy) that has not responded to standard treatments. **You may be eligible if...** - You have been diagnosed with dilated cardiomyopathy (an enlarged, weakened heart) - You have significant symptoms despite taking optimal medications and using any recommended heart devices for at least 3 months - Your heart's pumping ability (ejection fraction) is 35% or less - No other standard treatment options are available to you **You may NOT be eligible if...** - You were born with a heart defect (congenital heart disease) - You have significant heart valve disease - You have other conditions that would make this treatment unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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