RecruitingNCT03582189

MR Guidance for Liver and Pancreas

A Feasibility Study of Magnetic Resonance Imaging (MRI) as a Platform for Image Guidance and Adaptive Radiation Therapy in Patients With Liver or Pancreatic Cancer

Sponsor

University Health Network, Toronto

Enrollment

30 participants

Start Date

Jul 11, 2018

Study Type

OBSERVATIONAL

Conditions

Magnetic Resonance Imaging

Summary

This is a single centre, single arm, prospective feasibility study that aims to see whether magnetic resonance imaging (MRI) as a source of image guidance before each radiation treatment fraction is feasible, and also if it may provide information that could potentially be used during the treatment to improve the radiation treatment plan. Patients will have 5 MRIs with each of their RT sessions. If patients' RT treatment will consist of more than 5 fractions, only 5 MRIs will be done with any 5 RT fractions. Patients will be completing a short questionnaire at the end of each MRI. A patient questionnaire will also be completed at the end of the study to assess for patient satisfaction. There will be 30 evaluable patients enrolled to the study.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study uses MRI guidance during radiation therapy for liver or pancreatic cancer to improve the accuracy and safety of treatment, allowing doctors to better target the tumor while protecting surrounding healthy tissue. **You may be eligible if...** - You are 18 years of age or older - You have been diagnosed with locally advanced pancreatic cancer or liver cancer (hepatocellular carcinoma) - You are being considered for treatment with chemotherapy combined with radiation, long-course radiation therapy, or a focused radiation technique called stereotactic body radiation therapy (SBRT) - Your treatment plan involves 5 or more radiation sessions **You may NOT be eligible if...** - You have a contraindication to MRI scanning, such as a ferromagnetic prosthesis (certain metal implants), a pacemaker or implanted defibrillator, or severe claustrophobia Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERMRI

Patients who consent to this study will have an abdominal MRI prior to or immediately after each fraction of radiation treatment in the case of those patients that are undergoing SBRT or those receiving palliative treatment. On patients receiving definitive chemoradiation, an abdominal MRI will be performed prior to or immediately after radiation treatment once per week during the any five weeks of treatment