RecruitingPhase 2NCT05336188

Neurocognitive Mechanisms Underlying Smartphone-Assisted Prevention of Relapse in Opioid Use Disorder


Sponsor

University of Arkansas

Enrollment

255 participants

Start Date

May 16, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The proposed clinical trial would evaluate the use of smartphone applications ("apps", which have well-established efficacy in reducing cigarette and alcohol use) to prevent relapse among patients receiving medication-assisted treatment for opioid use disorder. In addition to standard app-based self-monitoring of drug use and personalized feedback, project innovation is enhanced by the proposed use of location-tracking technology for targeted, personalized intervention when participants enter self-identified areas of high risk for relapse. Furthermore, the proposed sub-study would use longitudinal functional neuroimaging to elucidate the brain-cognition relationships underlying individual differences in treatment outcomes, offering broad significance for understanding and enhancing the efficacy of this and other app-based interventions.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study investigates how a smartphone app can support people in medication-assisted treatment (MAT) for opioid use disorder and help prevent relapse. It also includes an optional brain imaging (MRI) component to understand the brain mechanisms involved. You may be eligible if: - You are 18 years old or older - You are in Phase I of medication-assisted treatment for opioid use disorder (receiving weekly clinic visits with limited take-home doses) - You are willing to use a smartphone if assigned to the app intervention group You may NOT be eligible (for the MRI sub-study) if: - You have a history of neurological, cardiovascular, or infectious disease - You have had a loss of consciousness of 20 or more minutes or brain trauma - You are pregnant - You have MRI contraindications (metal implants, claustrophobia, etc.) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICESmartphone

Adjunctive Smartphone app for improving MAT outcomes


Locations(1)

Brain Imaging Research Center

Little Rock, Arkansas, United States

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NCT05336188


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