Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis

This trial is studying whether a stem cell transplant using a patient's own stem cells (collected, treated, and returned to the patient) can help children, teenagers, young adults, and adults with severe systemic sclerosis (scleroderma), a serious autoimmune disease that causes the immune system to attack and stiffen the skin and internal organs. **You may be eligible if...** - For the children/young adult group: you are between 8 and 24 years old, were diagnosed with systemic sclerosis at or before age 19, and have not responded to at least 2 prior medications - For adults: specific adult criteria apply as defined in the protocol - You have given written informed consent (or your parent/guardian has) **You may NOT be eligible if...** - Your disease has not been confirmed as systemic sclerosis - You have responded well to prior treatments - You have serious organ dysfunction that would make a transplant unsafe - You are pregnant Talk to your doctor to see if this trial is right for you.