Adjuncts for Adductor Block: Dexamethasone,Dexmedetomidine, or Combination to Reduce Pain
Adjuncts for Adductor Block: Dexamethasone,Dexmedetomidine, or Combination to Reduce Pain. A Randomized Controlled Comparison of the Analgesic Effects Following ACL Repair
Women's College Hospital
252 participants
Feb 21, 2020
INTERVENTIONAL
Conditions
Summary
The aim of this multi-centered study is to evaluate the effects of two distinct Adductor Canal Block (ACB) adjuncts, dexamethasone and dexmedetomidine, and their combination, on postoperative analgesia in patients undergoing Anterior Cruciate Ligament (ACL) Repair.
Eligibility
Inclusion Criteria3
- English Speaking
- ASA 1-3 patients
- BMI <40
Exclusion Criteria11
- Refusal or inability to provide informed consent
- Any contraindication to regional anesthesia including coagulopathy or bleeding diathesis, allergy to local anesthetics, infection, nerve injury or malignancy at the site of the block
- History of alcohol/drug dependence
- History of long term opioid intake or chronic pain disorder
- History of preexisting neuropathy in the operative leg
- History of significant psychiatric conditions that may affect patient assessment
- Inability to understand the informed consent and demands of the study
- Allergy to any of the components of the multimodal analgesic regimen
- Revision of ACL repair
- Diabetes
- Significant bradycardia (baseline heart rate ≤ 40 beats per minute)
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Interventions
To guarantee rapid onset as well as effective postoperative analgesia, a 20 mL volume of local anesthetic has been selected for performing the ACB. The block solution will be a 20 ml volume for all groups, prepared by mixing 18 ml of ropivacaine 0.5% mixed with an additional 2 ml prepared according to the randomization.
To guarantee rapid onset as well as effective postoperative analgesia, a 20 mL volume of local anesthetic has been selected for performing the ACB. The block solution will be a 20 ml volume for all groups, prepared by mixing 18 ml of ropivacaine 0.5% mixed with an additional 2 ml prepared according to the randomization.
Control/Placebo intervention
Locations(1)
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NCT03643822