ACL Injury Clinical Trials

18 recruiting

ACL Injury Trials at a Glance

18 actively recruiting trials for acl injury are listed on ClinicalTrialsFinder across 6 cities in 9 countries. The largest study group is Not Applicable with 9 trials, with the heaviest enrollment activity in Ann Arbor, Asyut, and Atlanta. Lead sponsors running acl injury studies include Stefano Zaffagnini, Assiut University, and Ann & Robert H Lurie Children's Hospital of Chicago.

Browse acl injury trials by phase

Treatments under study

About ACL Injury Clinical Trials

Looking for clinical trials for ACL Injury? There are currently 18 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new ACL Injury trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about ACL Injury clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 118 of 18 trials

Recruiting

Baseline ACL Injury Risk Screening and Normative Data

Anterior Cruciate Ligament InjuriesACL Injury
Sanford Health5,000 enrolled1 locationNCT06635668
Recruiting
Not Applicable

Study of Functional Magnetic Resonance Signal Variations in Patients Undergoing Anterior Cruciate Ligament Reconstruction With the Application of a Dedicated Neuromotor Training

Rehabilitation ExerciseACL InjuryfMRI+1 more
Stefano Zaffagnini12 enrolled1 locationNCT07097077
Recruiting
Not Applicable

Michigan Split-belt Treadmill Training Program to Improve Acute Knee Biomechanics After ACL Reconstruction

ACL InjuryACL
University of Michigan30 enrolled1 locationNCT06529679
Recruiting

ACL Reconstruction: Clinical Outcome

ACL Injury
Stefano Zaffagnini1,000 enrolled1 locationNCT03441659
Recruiting
Not Applicable

Muscle O2 Saturation and Hemoglobin Levels During Rehabilitation From Arthroscopic Surgery

ACL InjuryHip Injuries
University Hospitals Cleveland Medical Center226 enrolled2 locationsNCT05488054
Recruiting
Not Applicable

Augmentation of Partial Anterior Cruciate Ligament Tear: Early Results

ACL InjuryACL Augmentation
Assiut University30 enrolled1 locationNCT05391672
Recruiting
Phase 4

Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction

Anterior Cruciate Ligament InjuriesACL InjuryPost-Traumatic Osteoarthritis of Knee+1 more
Hospital for Special Surgery, New York40 enrolled2 locationsNCT06311513
Recruiting

Rehabilitation Treatment of Anterior Cruciate Ligament Rupture

ACL Injury
Aarhus University Hospital400 enrolled1 locationNCT04408885
Recruiting
Not Applicable

Mindfulness and ACL Surgery

ACL InjuryACL
University of Wisconsin, Madison200 enrolled1 locationNCT05542563
Recruiting
Early Phase 1

MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)

Post-traumatic OsteoarthritisACL InjuryMeniscus Tear
Austin V Stone30 enrolled1 locationNCT04572256
Recruiting
Phase 4

Adjuncts for Adductor Block: Dexamethasone,Dexmedetomidine, or Combination to Reduce Pain

ACL Injury
Women's College Hospital252 enrolled1 locationNCT03643822
Recruiting
Not Applicable

The Pediatric ALL Evaluation and Trial

ACL InjuryACL Tear
Ann & Robert H Lurie Children's Hospital of Chicago240 enrolled1 locationNCT04825587
Recruiting

Association Between Neuromuscular Parameters and Functional Assessment After ACL Reconstruction

ACL Injury
University Hospital, Caen25 enrolled1 locationNCT06524869
Recruiting
Not Applicable

Immediate Versus Optional Delayed Surgical Repair for Treatment of Acute ACL Injuries

ACL Injury
Universitaire Ziekenhuizen KU Leuven280 enrolled1 locationNCT05747079
Recruiting
Not Applicable

The Efficiency and Safety of PRP Treatment After Anterior Cruciate Ligament Reconstruction.

Knee OsteoarthritisACL Injury
Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz60 enrolled1 locationNCT06442319
Recruiting
Not Applicable

Kinesiophobia After Anterior Cruciate Ligament Reconstruction.

KinesiophobiaACL Injury
Tartu University Hospital144 enrolled1 locationNCT05762809
Recruiting

Anterior Cruciate Ligament Study

ACL InjuryACL
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio370 enrolled1 locationNCT06194682
Recruiting

The Faroese Knee Cohort: Etiology and Long-term Implications of Trochlear Dysplasia and Patellar Dislocations.

ACL InjuryMeniscus LesionPatellar Dislocation+1 more
Hvidovre University Hospital100 enrolled1 locationNCT04607538