T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias

This study offers bone marrow transplantation using donors who are not a perfect tissue match (alternative donors) for patients with sickle cell disease or other serious anemias such as beta-thalassemia and Diamond-Blackfan anemia. Standard bone marrow transplants require a closely matched sibling donor, which many patients don't have. This trial uses a special technique called T-cell depletion to reduce the risk of rejection and graft-versus-host disease, making transplants from partially matched donors safer. The goal is to give patients without a perfect donor a chance at a cure. The transplant can eliminate or greatly reduce the need for blood transfusions and prevent serious complications like strokes, pain crises, and organ damage caused by sickle cell disease. You may be eligible if: - You are between 5 and 40 years of age - You have sickle cell disease (HbSS or Sβ0-thalassemia) with serious complications such as recurrent pain crises, acute chest syndrome, stroke, or organ damage - OR you have beta-thalassemia or Diamond-Blackfan anemia requiring regular blood transfusions - You do not have a fully matched sibling or unrelated donor available - Your organs (heart, lungs, liver, kidneys) are functioning adequately - You have tried and failed hydroxyurea (for sickle cell disease) You may NOT be eligible if: - You have a fully matched sibling or matched unrelated donor available - You have had a stem cell transplant within the past 6 months - You have had a central nervous system event (e.g., stroke) within the past 6 months - You are pregnant or breastfeeding - You have an active, uncontrolled infection Talk to your doctor to see if this trial is right for you.