RecruitingPhase 2NCT06016634
Alendronate for Osteonecrosis in Adults With Sickle Cell Disease
A Feasibility Study of Alendronate as Treatment for Osteonecrosis in Adults With Sickle Cell Disease
Sponsor
University of California, Davis
Enrollment
30 participants
Start Date
Mar 9, 2026
Study Type
INTERVENTIONAL
Conditions
Summary
A prospective, single-arm, intervention study of oral alendronate in adults with sickle cell disease and osteonecrosis
Eligibility
Min Age: 18 YearsMax Age: 80 Years
Inclusion Criteria4
- Age 18-80 years with SCD (any genotype, confirmed by hemoglobin electrophoresis or high performance liquid chromatography)
- Ability to provide written informed consent
- Ability to lay on a dual-energy X-ray absorptiometry (DXA) scanner
- Negative urine pregnancy test for anyone of childbearing potential at study entry
Exclusion Criteria5
- Pregnant women
- Adults unable to consent
- Individuals who are not yet adults (infants, children, teenagers)
- Prisoners
- Hospitalizations (for any cause) within 2 weeks of study entry
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Interventions
DRUGAlendronate Sodium
Administer oral alendronate 70 mg once a week x 24 weeks to all study participants
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06016634
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