ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease

This trial is testing a non-invasive procedure that uses focused ultrasound waves (guided by MRI) to temporarily open the brain's natural protective barrier — the blood-brain barrier — in Alzheimer's patients, allowing medications to better reach brain tissue. **You may be eligible if...** - You are between 50 and 85 years old - You have been diagnosed with probable Alzheimer's disease - If you take Alzheimer's medication, you have been on a stable dose for at least 3 months - You are mobile (ambulatory) and able to communicate during the procedure **You may NOT be eligible if...** - Your MRI shows certain abnormalities (like significant bleeding, large strokes, or structural problems) that make the procedure risky - You have metal implants in your body that are unsafe in MRI (e.g., certain pacemakers, cochlear implants, or aneurysm clips) - You have a history of brain surgery or significant neurological conditions beyond Alzheimer's - You are unable to tolerate the procedure (e.g., severe claustrophobia) - You are pregnant Talk to your doctor to see if this trial is right for you.