Genomic Investigation of Unusual Responders

Inclusion Criteria7

• The patient must have either an exceptionally good or poor response to treatment, as indicated by their treating physician.
• The exact definition of this is adaptable to the disease but a suggested guideline is a Complete Response, Partial Response or progression free interval of at least 6 months
• Exceptionally poor response includes patients who were expected to respond favourably to a treatment but instead responded poorly (e.g dramatic tumor growth or death)
• The patient must have sufficient archival tumor available for sequencing.
• Deceased patients will also be considered for analysis (up to 30 patients per year) if they meet at least one of the following requirements:
• a)) Patients who have archival tissue stored within the UHN Laboratory Medicine Program who have had a consent waiver granted by the REB to access the tissue.
• b) Patients who have archival tissue banked for further research within the UHN Biospecimen Sciences Program