RecruitingNCT03774758

Biomarkers for Risk Stratification in Lung Cancer

Circulating Tumor DNA for Risk Stratification in Lung Cancer Screening


Sponsor

University of California, San Francisco

Enrollment

590 participants

Start Date

Dec 17, 2017

Study Type

OBSERVATIONAL

Conditions

Summary

This is a prospective observational study that will follow patients who undergo lung cancer screening at the San Francisco VA Medical Center, University of California, San Francisco (UCSF) Medical Center, and the San Francisco General Hospital. The proposed study will comprise of two primary populations to determine the ctDNA assay performance in a variety of clinical settings.


Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study is searching for blood-based biomarkers — measurable biological signals in the blood — that could help identify people at higher or lower risk of developing lung cancer before symptoms appear. Early detection of lung cancer dramatically improves survival chances, but current screening methods are imperfect. By studying blood samples from participants over three years and comparing them with who develops lung cancer, researchers hope to find reliable early warning signals. **You may be eligible if...** - You are 40 years of age or older - You can understand the study and provide written informed consent - You are willing to provide blood samples at required time points - You are willing to complete three years of follow-up visits and check-ins **You may NOT be eligible if...** - You have had an active non-skin cancer within the past 5 years - You are unable or unwilling to commit to the 3-year follow-up period - You cannot provide blood samples as required Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTGuardant Health ct-DNA LUNAR assay

Guardant Health is focused on conquering cancer by using its breakthrough blood-based assays, vast data sets, and advanced analytics. In 2016, it announced Project LUNAR, an effort to apply Guardant Health's technology platform to early detection, recurrence monitoring, and assessing minimal residual disease.


Locations(3)

Zuckerberg San Francisco General Hospital and Trauma Center

San Francisco, California, United States

San Francisco VA Medical Center

San Francisco, California, United States

University of California, San Francisco

San Francisco, California, United States

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NCT03774758


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