Ischemic Postconditioning in STEMI Patients Treated With Primary PCI
The Effect of Ischemic Postconditioning in Patients With STEMI Undergoing Primary PCI (DANAMI4-iPOST2)
Rigshospitalet, Denmark
1,800 participants
Feb 4, 2019
INTERVENTIONAL
Conditions
Summary
In a prospective, randomized clinical trial the iPOST2 trial will determine whether ischemic postconditioning reduces reperfusion injury and this will translate into improved clinical outcome of heart failure and death for STEMI patients who present with TIMI0-1 undergoing primary PCI
Eligibility
Inclusion Criteria4
- Age ≥18 years
- Acute onset of chest pain with < 12 hours duration
- STEMI as characterized by 2 mm ST elevation in 2 or more V1 through V4 leads or presumed new left bundle branch block with minimum of 1 mm concordant ST elevation or 1 mV ST-segment elevation in the limb lead (II, III and aVF, I, aVL) and V4-V6 or ST depression in 2 or more V1 through V4 leads indicating posterior AMI.
- TIMI flow 0-1 in infarct related artery
Exclusion Criteria4
- Potential pregnancy
- Refusal to participate
- OHCA without subsequent consciousness despite ROSC
- Thrombectomy considered unavoidable
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Interventions
After 60 seconds of reperfusion, ischemic postconditioning with an adequately sized balloon (60 reperfusion/60 seconds re-occlusion, four cycles) will be performed
State of the art primary PCI, however thrombectomy is not allowed
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03787745