Prospective Observational Trial to Evaluate Quality of Life After Definitive Chemoradiation in Patients With Anal Cancer (LANACARE)

This study is monitoring and recording quality of life in patients with anal cancer (cancer of the anal canal) who are receiving a combined chemotherapy and radiation treatment — without surgery — as their primary therapy. The study uses standardized questionnaires to track physical symptoms, bowel function, emotional wellbeing, and daily activities over time. Understanding how patients feel and function during and after this treatment will help doctors and patients better prepare for and manage the effects of chemoradiation. **You may be eligible if...** - You have been diagnosed with anal cancer confirmed by biopsy, without spread to distant organs - Your specialist team recommends chemoradiation as your main treatment - You are 18 years or older - You are able to understand and complete the required questionnaires **You may NOT be eligible if...** - You are under 18 years old - You have previously received systemic therapy (chemotherapy) for anal cancer - You cannot complete the standardized questionnaires on your own Talk to your doctor to see if this trial is right for you.