Anal Cancer Clinical Trials

36 recruiting

Anal Cancer Trials at a Glance

38 actively recruiting trials for anal cancer are listed on ClinicalTrialsFinder across 6 cities in 14 countries. The largest study group is Not Applicable with 12 trials, with the heaviest enrollment activity in Gothenburg, New Brunswick, and Chicago. Lead sponsors running anal cancer studies include Christian Hinrichs, Aarhus University Hospital, and Fondazione Policlinico Universitario Agostino Gemelli IRCCS.

Browse anal cancer trials by phase

Treatments under study

About Anal Cancer Clinical Trials

Looking for clinical trials for Anal Cancer? There are currently 36 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Anal Cancer trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Anal Cancer clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 38 trials

Recruiting

DESTINY-PANTUMOUR04

Liver CancerEsophageal CancerPancreatic Cancer+24 more
AstraZeneca100 enrolled17 locationsNCT07124000
Recruiting
Not Applicable

Screening for Anal Cancer in Men Who Have Sex With Men Using Pre-Exposure Prophylaxis

Anal CancerSquamous Cell CarcinomaSquamous Intraepithelial Lesions+3 more
Universitair Ziekenhuis Brussel296 enrolled8 locationsNCT07029152
Recruiting
Not Applicable

Self-sampling to Optimize Anal Lesion Outcomes

Anal Cancer
Medical College of Wisconsin572 enrolled3 locationsNCT07192055
Recruiting
Phase 2

Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer

HIV InfectionAnal Squamous Cell CarcinomaStage II Rectal Cancer AJCC v8+7 more
National Cancer Institute (NCI)40 enrolled14 locationsNCT04929028
Recruiting
Phase 2

Study of Pembrolizumab, Carboplatin, Paclitaxel, and Radiation for the Treatment of Early-Stage Anal Cancer

Anal Cancer
Dustin Deming23 enrolled4 locationsNCT06493019
Recruiting
Not Applicable

Intrafractional Vaginal Dilation in Anal Cancer Patients Undergoing Pelvic Radiotherapy

Anal Cancer
Juergen Debus60 enrolled1 locationNCT04094454
Recruiting

Detecting HPV DNA in Anal and Cervical Cancers

Cervical CancerAnal CancerHPV-Related Anal Squamous Cell Carcinoma+3 more
University of Chicago20 enrolled2 locationsNCT04857528
Recruiting
Phase 1Phase 2

E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers

Cervical CancerAnal CancerPenile Cancer+14 more
Christian Hinrichs15 enrolled2 locationsNCT05639972
Recruiting
Phase 2

E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers

Cervical CancerMetastatic CancerAnal Cancer+18 more
Christian Hinrichs20 enrolled3 locationsNCT05686226
Recruiting
Not Applicable

Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

Liver CancerBiliary Tract CancerColon Cancer+76 more
Cedars-Sinai Medical Center360 enrolled1 locationNCT04907643
Recruiting

HPV Genotype Attribution and Disease Burden of Anal Cancer in China

Anal Cancer
Fudan University300 enrolled1 locationNCT06670495
Recruiting
Not Applicable

Ganglion Impar Neurolysis for the Improvement of Radiation-Induced Pain During Localized Anal or Perianal Skin Cancer Treatment

Localized Anal CarcinomaLocalized Anal Margin CarcinomaStage 0 Anal Cancer AJCC v8+3 more
Emory University5 enrolled2 locationsNCT07112690
Recruiting

Integrated Cancer Repository for Cancer Research

Breast CancerLiver CancerEsophageal Cancer+47 more
University of Nebraska999,999 enrolled45 locationsNCT02012699
Recruiting
Phase 2

Dynamic ctDNA Assessment in Cervical and Anal Canal Tumors: Optimizing Follow-up and Clinical Outcomes

HPV-Related Anal Squamous Cell CarcinomaHPV-Related Cervical CarcinomaHPV-Related Carcinoma+2 more
Instituto do Cancer do Estado de São Paulo150 enrolled1 locationNCT06640283
Recruiting

Beyond Survival: Addressing Gynecological and Sexual Health in Women After Radiotherapy for Anal Cancer

Anal Cancer
Aarhus University Hospital80 enrolled3 locationsNCT07296237
Recruiting
Phase 1Phase 2

A Study in Advanced or Metastatic Gastrointestinal Cancers Exploring Treatment Combinations With Pelareorep and Atezolizumab

Pancreatic Cancer MetastaticAnal Cancer MetastaticSquamous Cell Carcinoma of the Anus Stage Unspecified+1 more
Oncolytics Biotech122 enrolled15 locationsNCT07280377
Recruiting
Not Applicable

Identification of Molecular Signatures of High-risk Oncogenic HPV and Study of Their Associations With the Presence of High-grade Lesions and/or Anal Cancer 10 Years After Inclusion in the ANRS IPERGAY Trial

Anal CancerHPV Infection
ANRS, Emerging Infectious Diseases100 enrolled3 locationsNCT06522256
Recruiting
Phase 2

Inguinal Node Sparing Radiotherapy For Patients With Early Stage Anal Cancer

Anal Canal Cancer
AHS Cancer Control Alberta45 enrolled1 locationNCT05040815
Recruiting
Not Applicable

Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers

Metastatic Gastroesophageal Junction AdenocarcinomaMetastatic Hepatocellular CarcinomaStage IV Hepatocellular Carcinoma AJCC v8+41 more
University of California, San Francisco28 enrolled2 locationsNCT04221893
Recruiting

Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women

Breast CancerLiver CancerGastric Cancer+9 more
Washington University School of Medicine10 enrolled1 locationNCT06904365