Etiology and Treatment of Neonatal Seizure

This study is investigating the causes of neonatal seizures and early-onset epilepsy in infants — specifically those with seizures of unknown origin. By conducting genetic testing and analysis, researchers aim to identify the underlying genetic mutations responsible, which could lead to more targeted treatments and better outcomes for affected children. You may be eligible if: - Your infant experienced severe seizures, generalized epilepsy, or intractable (hard-to-control) epilepsy before 1 year of age - The seizures are of unknown or unclear cause (no identified metabolic disorder, infection, or structural problem) You may NOT be eligible if: - The seizures were caused by a known factor: trauma, central nervous system infection, hypoxic-ischemic encephalopathy, vascular events, systemic infections, or a diagnosed metabolic disorder - A genetic copy-number variant has already been identified by chromosomal microarray (CGH) Talk to your child's pediatric neurologist about whether a genetic workup has already been completed and whether the seizure cause remains unexplained before applying.