RecruitingNCT03822741

Etiology and Treatment of Neonatal Seizure

Gene Profiling and Individualized Treatment of Neonatal Seizure in China

Sponsor

Children's Hospital of Fudan University

Enrollment

2,000 participants

Start Date

Aug 8, 2016

Study Type

OBSERVATIONAL

Conditions

Seizures Seizure Disorder Seizure Newborn Seizure Generalized

Summary

Genetic diagnosis for neonates suffering from epilepsy has important implications for treatment, prognosis, and development of precision medicine strategies. Investigator performed exome sequencing (ES) or targeted sequencing on neonates with seizure onset within the first month of life. Investigator subgrouped our patients based on the onset age of seizure into neonatal and before 1 year (1-12 months), to compare the clinical and genetic features and treatment strategies.

Eligibility

Max Age: 12 Months

Inclusion Criteria3

severe seizures in neonates or generalized epilepsy or intractable epilepsy in infancy with generalized tonic-clonic seizures,
seizures onset before 1 year of age,
epileptic syndromes/epileptic-encephalopathies with unknown etiology.

Exclusion Criteria1

Patients were excluded if they had traumas, central nervous system infections, hypoxic-ischemic encephalopathy, vascular events, systemic infections, and diagnosed metabolic disorders, and pathogenic copy-number variants were identified using array-based comparative genomic hybridization (CGH).

Print for Your Doctor

Interested in this trial?

Get notified about updates and connect with the research team.