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RecruitingNCT03825458

Creation of a Cohort for the Quantitation and Characterization of Circulating Viral RNAs as a New Biomarker of Hepatitis B Functional Cure.

Sponsor

Hospices Civils de Lyon

Enrollment

3,500 participants

Start Date

Feb 25, 2019

Study Type

OBSERVATIONAL

Conditions

Hepatitis B

Summary

The " CirB-RNA " cohort aims to create a biological collection associated with clinical and biological data from patients with hepatitis B infection. This project is part of a much larger program that aims to characterize and quantify circulating viral RNAs as a possible new biomarker of hepatitis B functional cure.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

  • Adults patients and minor children over 6 years of age (in Lyon) with acute or chronic hepatitis B or presenting with HBsAg loss (with/without HBs seroconversion). (Co-infected patients with HDV and/or HCV and/or HIV are eligible)
  • Patients requiring blood sampling for medical care at the time of the medical appointment.
  • Informed patients who do not refuse to participate.
  • Persons not affiliated to a social security scheme and persons receiving medical assistance from the state may be asked to participate in the study

Exclusion Criteria4

  • Patients participating at the time of the inclusion to an interventional trial evaluating a drug likely to interfere with this study.
  • Persons deprived of their liberty by a judicial or administrative decision
  • Adults who are subject to a legal protection measure
  • Children less than 6 years old (in Lyon)

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Interventions

OTHERBlood sampling

Blood sampling at each clinical follow-up visit.

Locations(6)

Hepatology department - Groupement Hospitalier Nord - Hôpital de la Croix-Rousse

Lyon, France

Hôpital de la Croix-Rousse - Service de maladies infectieuses et tropicales

Lyon, France

Department of Hepato-gastroenterology and pediatric nutrition - Hôpital Femme-Mère Enfant

Lyon, France

Gastroenterology and Hepatology department - • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Milan, Italy

Gastroenterology and Hepatology department - • Università degli Studi di Palermo

Palermo, Italy

Infectious diseases and hepatology unit - Azienda Ospedaliero

Parma, Italy

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