Hepatitis B Clinical Trials

139 recruitingLast updated: June 18, 2026

There are 139 actively recruiting hepatitis b clinical trials across 38 countries. Studies span Phase 2, Phase 1, Not Applicable, Phase 4, Phase 3, Early Phase 1. Top locations include Guangzhou, Guangdong, China, Beijing, Beijing Municipality, China, Baltimore, Maryland, United States. Updated daily from ClinicalTrials.gov.


Hepatitis B Trials at a Glance

139 actively recruiting trials for hepatitis b are listed on ClinicalTrialsFinder across 6 cities in 38 countries. The largest study group is Phase 2 with 29 trials, with the heaviest enrollment activity in Guangzhou, Beijing, and Baltimore. Lead sponsors running hepatitis b studies include Third Affiliated Hospital, Sun Yat-Sen University, Ausper Biopharma Co., Ltd., and Beijing Continent Pharmaceutical Co, Ltd..

Browse hepatitis b trials by phase

Treatments under study

About Hepatitis B Clinical Trials

Looking for clinical trials for Hepatitis B? There are currently 42 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Hepatitis B trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Hepatitis B clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 139 trials

Recruiting
Phase 1Phase 2

TherVacB - A Heterologous Protein Prime/MVA Boost Therapeutic Hepatitis B Vaccine Candidate

Chronic Hepatitis B
Michael Hoelscher81 enrolled6 locationsNCT06513286
Recruiting
Phase 2

Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States

CirrhosisCirrhosis, LiverCirrhosis Due to Hepatitis B+5 more
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)256 enrolled13 locationsNCT05832229
Recruiting
Phase 2

VIR-2218 and Peginterferon Alfa-2a for Chronic Hepatitis B

Chronic Hepatitis B
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)50 enrolled1 locationNCT06092333
Recruiting
Phase 2

Phase 2 Study of AHB-137 in HBeAg Negative Chronic Hepatitis B (CHB) Participants in Asia Pacific Region

Hepatitis B, Chronic
AusperBio Therapeutics Inc.84 enrolled8 locationsNCT07370207
Recruiting
Phase 1

A Phase I Clinical Study of AHB - 171 in Healthy Participants(HP) and Chronic Hepatitis B (CHB) Participants

Chronic Hepatitis B Infection
Ausper Biopharma Co., Ltd.110 enrolled1 locationNCT07511218
Recruiting
Phase 1

Safety and Antiviral Activity of a Monoclonal Hepatitis B Antibody: a Phase 1b, Open-label Trial in Individuals With Chronic Hepatitis D Infection

Hepatitis D, ChronicHepatitis B Chronic Infection
Aarhus University Hospital15 enrolled2 locationsNCT07610772
Recruiting

Evaluation of Patients With Liver Disease

Hepatitis BHepatitis CLiver Disease+1 more
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)8,050 enrolled1 locationNCT00001971
Recruiting
Phase 1

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of GIGA-2339 in Participants With Chronic Hepatitis B Virus Infection

Hepatitis B Virus Infection
GigaGen, Inc.48 enrolled17 locationsNCT07024641
Recruiting

Creation of a Cohort for the Quantitation and Characterization of Circulating Viral RNAs as a New Biomarker of Hepatitis B Functional Cure.

Hepatitis B
Hospices Civils de Lyon3,500 enrolled6 locationsNCT03825458
Recruiting
Not Applicable

Gene Discovery in CHB Patients to Identify Unknown Pathways That Lead to B and NK Cell Deregulation

Chronic Hepatitis B Virus
University Hospital, Limoges140 enrolled3 locationsNCT06853886
Recruiting

Real World Assessment of People Living With Chronic Hepatitis B in Australia

Hepatitis B
Kirby Institute10,000 enrolled19 locationsNCT04914611
Recruiting
Phase 2

A Multicenter Study of AHB-137 Injection Combined With Other Hepatitis B Drugs

Chronic Hepatitis B
Ausper Biopharma Co., Ltd.200 enrolled1 locationNCT07069569
Recruiting

Adaptability of an Undetectable = Untransmissible Model for HBV

Chronic Hepatitis BViremia
NYU Langone Health55 enrolled1 locationNCT07449091
Recruiting
Not Applicable

Assessment of Treatment Adherence and Associated Factors in Chronic HepB Patients Supported by HBVCare

Chronic Hepatitis B
Institute of Gastroenterology and Hepatology, Vietnam70 enrolled2 locationsNCT07540637
Recruiting
Phase 4

Tenofovir Alafenamide Versus Entecavir for the Treatment of Chronic Hepatitis B

Hepatitis BViral Hepatitis
Taichung Veterans General Hospital140 enrolled1 locationNCT03933384
Recruiting

Hep Mec Cohort in Zambia

Hepatitis BHIV
University of Alabama at Birmingham390 enrolled3 locationsNCT07589985
Recruiting
Phase 4

ASC22 Combined With Peg-IFNa in Achieving Functional Cure in Patients With Chronic Hepatitis B Virus Infection

Chronic Hepatitis B
The Second Affiliated Hospital of Chongqing Medical University150 enrolled1 locationNCT07573943
Recruiting
Phase 2

A Study to Evaluate the Efficacy and Safety of AHB-137 Injection in Participants With Chronic Hepatitis B (CHB)

Chronic Hepatitis B
Ausper Biopharma Co., Ltd.60 enrolled1 locationNCT07137910
Recruiting

Long-term Follow-up Study to Evaluate Participants With Chronic Hepatitis B (CHB) Previously Treated With AHB-137 Injection

Chronic Hepatitis B
Ausper Biopharma Co., Ltd.200 enrolled2 locationsNCT07146100
Recruiting
Phase 2

A Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg- Negative Adult Subjects With Chronic Hepatitis B (B-SUPREME)

Chronic Hepatitis B Infection
Aligos Therapeutics200 enrolled58 locationsNCT06963710