Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for SAH
Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for Severe Alcoholic Hepatitis (SAH)
Johns Hopkins University
200 participants
Nov 20, 2020
INTERVENTIONAL
Conditions
Summary
Given the severe consequences of alcohol relapse following liver transplantation for alcoholic hepatitis (AH-LT), it is critical to accurately identify alcohol use and implement alcohol interventions early in the post-transplant period to optimize patient outcomes. The proposed randomized clinical trial will examine the implementation and effects of integrated, person- and computer-delivered alcohol treatment compared to standard care on alcohol use (assessed by self-report and biomarker), mood, quality of life and survival following AH-LT. Predictors of 12-month post-transplant alcohol outcomes will be explored to allow future improved tailoring and targeting of these treatments.
Eligibility
Inclusion Criteria1
- English speaking
Exclusion Criteria2
- too medically/psychiatrically ill to participate
- not able to provide informed consent due to cognitive impairment
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Interventions
IAT will include computer-delivered BI in the hospital, nurse-delivered alcohol monitoring counseling at each outpatient LT follow-up visit, and at-home participation in web-based, 7-session CBT4CBT, supplemented by tailored text messages.
Locations(1)
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NCT03845205