RecruitingNot ApplicableNCT03845205

Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for SAH

Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for Severe Alcoholic Hepatitis (SAH)


Sponsor

Johns Hopkins University

Enrollment

200 participants

Start Date

Nov 20, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

Given the severe consequences of alcohol relapse following liver transplantation for alcoholic hepatitis (AH-LT), it is critical to accurately identify alcohol use and implement alcohol interventions early in the post-transplant period to optimize patient outcomes. The proposed randomized clinical trial will examine the implementation and effects of integrated, person- and computer-delivered alcohol treatment compared to standard care on alcohol use (assessed by self-report and biomarker), mood, quality of life and survival following AH-LT. Predictors of 12-month post-transplant alcohol outcomes will be explored to allow future improved tailoring and targeting of these treatments.


Eligibility

Min Age: 18 Years

Inclusion Criteria1

  • English speaking

Exclusion Criteria2

  • too medically/psychiatrically ill to participate
  • not able to provide informed consent due to cognitive impairment

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Interventions

BEHAVIORALIntegrated AUD Treatment

IAT will include computer-delivered BI in the hospital, nurse-delivered alcohol monitoring counseling at each outpatient LT follow-up visit, and at-home participation in web-based, 7-session CBT4CBT, supplemented by tailored text messages.


Locations(1)

Johns Hopkins University School of Medicine

Baltimore, Maryland, United States

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NCT03845205


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