Alcohol Use Disorder Clinical Trials

157 recruiting

Alcohol Use Disorder Trials at a Glance

189 actively recruiting trials for alcohol use disorder are listed on ClinicalTrialsFinder across 6 cities in 21 countries. The largest study group is Not Applicable with 94 trials, with the heaviest enrollment activity in New Haven, Baltimore, and Bethesda. Lead sponsors running alcohol use disorder studies include Yale University, National Institute on Alcohol Abuse and Alcoholism (NIAAA), and Medical University of South Carolina.

Browse alcohol use disorder trials by phase

Treatments under study

About Alcohol Use Disorder Clinical Trials

Looking for clinical trials for Alcohol Use Disorder? There are currently 157 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Alcohol Use Disorder trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Alcohol Use Disorder clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 189 trials

Recruiting
Phase 2

Semaglutide Therapy for Alcohol Reduction (STAR)

Alcohol Use DisorderAddiction
National Institute on Drug Abuse (NIDA)67 enrolled1 locationNCT06015893
Recruiting
Phase 1

Environment and Alcohol: A Pilot Study

Alcohol Use Disorder
National Institute on Drug Abuse (NIDA)44 enrolled1 locationNCT06860607
Recruiting
Phase 2

Human Laboratory Study of Apremilast for Alcohol Use Disorder

Alcohol Use DisorderAlcohol Misuse
National Institute on Alcohol Abuse and Alcoholism (NIAAA)100 enrolled3 locationsNCT07325266
Recruiting

NIAAA Natural History Protocol

Alcohol Use Disorder
National Institute on Alcohol Abuse and Alcoholism (NIAAA)7,500 enrolled1 locationNCT02231840
Recruiting
Phase 1

Spironolactone in Alcohol Use Disorder (SAUD)

Alcohol Use Disorder
National Institute on Drug Abuse (NIDA)20 enrolled1 locationNCT05807139
Recruiting
Phase 2

Motivation for IV Alcohol Self-Administration in Humans

Alcohol Use Disorder
University of California, Los Angeles210 enrolled1 locationNCT06494891
Recruiting

Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics

Healthy VolunteerTobacco Use DisorderMigraine+7 more
Yale University200 enrolled2 locationsNCT06624137
Recruiting
Phase 2

Brexpiprazole in Alcohol Use Disorder

Alcohol Use Disorder
University of Colorado, Denver250 enrolled1 locationNCT04066192
Recruiting
Phase 1

The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)

Alcohol Use Disorder (AUD)Alcohol-Related DisordersAlcohol Use
Yale University63 enrolled1 locationNCT06070649
Recruiting
Not Applicable

New Relapse Model in Psychiatry

Alcohol Use Disorder
Cliniques universitaires Saint-Luc- Université Catholique de Louvain350 enrolled1 locationNCT06244641
Recruiting
Phase 1Phase 2

Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms

Healthy VolunteersAlcohol Use Disorder (AUD)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)180 enrolled1 locationNCT06484075
Recruiting
Phase 2

LSD Treatment for Persons With Alcohol Use Disorder

Alcohol Use Disorder (AUD)
Felix Mueller128 enrolled2 locationsNCT05474989
Recruiting
Phase 1

PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder

Alcohol Use Disorder
National Institute of Mental Health (NIMH)30 enrolled1 locationNCT06795581
Recruiting
Phase 2

Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

Alcohol Use DisorderPosttraumatic Stress Disorder
Texas A&M University200 enrolled2 locationsNCT05959434
Recruiting
Not Applicable

A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners

Alcohol DrinkingAlcohol Use DisorderMilitary Family+2 more
Stanford University744 enrolled1 locationNCT05619185
Recruiting
Phase 3

A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder

Alcohol Use Disorder
Eli Lilly and Company1,100 enrolled119 locationsNCT07219966
Recruiting
Phase 3

A Study of Brenipatide in Participants With Alcohol Use Disorder

Alcohol Use Disorder
Eli Lilly and Company1,100 enrolled114 locationsNCT07219953
Recruiting
Phase 1

Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)

Alcohol Use Disorder
National Institute of Mental Health (NIMH)30 enrolled1 locationNCT07027839
Recruiting
Not Applicable

Transcranial Magnetic Stimulation (TMS) Effects Using Magnetoencephalography (MEG) Study

Alcohol Use DisorderAlcohol ConsumptionAlcohol Dependence
Wake Forest University Health Sciences10 enrolled1 locationNCT06770556
Recruiting
Not Applicable

Implementation of Mobile-based Programs for Alcohol Cessation in Treatment of Alcohol-associated Liver Disease

Alcohol Use DisorderAlcohol-related Liver Disease
University of Wisconsin, Madison298 enrolled3 locationsNCT06305624