RecruitingNot ApplicableNCT03859297

Mechanisms of Rumination Change in Adolescent Depression

Developing Rumination-focused Treatment to Reduce Risk for Depression Recurrence (RDR) in Adolescence


Sponsor

Ohio State University

Enrollment

183 participants

Start Date

May 1, 2019

Study Type

INTERVENTIONAL

Conditions

Summary

This study will evaluate whether a newer treatment, rumination-focused cognitive behavioral treatment, which includes mindfulness and can be used to reduce ruminative habits, change ways in which key brain regions interact with each other (e.g.., often called connectivity), and whether these changes in habits and brain connectivity can reduce the risk for recurrence of depression in the next two years.


Eligibility

Min Age: 14 YearsMax Age: 17 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating the brain mechanisms behind rumination (repetitive negative thinking, which is a key feature of depression) in teenagers who have had depression, to understand what drives this pattern and how it can be changed by different types of therapy. **You may be eligible if...** - You are between 14 and 17 years old - You have previously been diagnosed with major depressive disorder and are now in full or partial remission (feeling somewhat better for at least two weeks) - You score above average on a questionnaire measuring rumination (repetitive negative thinking) - You have a parent or guardian willing to give consent, and you are willing to give assent to participate - You have an IQ above 75 (assessed during screening) - You have gone through puberty **You may NOT be eligible if...** - You are currently experiencing suicidal thoughts with a plan or intent to act on them, or have in the past three months - You have a history of conduct disorder, autism, psychosis, or bipolar disorder - You have had an eating disorder or substance use problem in the past 6 months Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALRumination-Focused CBT

RF-CBT targets rumination and other maladaptive forms of emotion regulation such as suppression and avoidance and provides skills training in effectively coping with rumination. RF-CBT specifically targets rumination through psychoeducation, adopting a functional analytic approach to the learned habitual behavior of rumination, and a focus on shifting process style. The adolescent is taught to notice triggers to ruminate as well as the consequences of rumination and to shift into practicing a more adaptive strategy such as an attention training exercise, behavioral activation, thinking in a concrete way, or active problem-solving. RF-CBT directly teaches adolescents to recognize rumination or "when the participant gets stuck in their head" and to notice the influence this has on their mood.

BEHAVIORALRelaxation-based Therapy

Sessions will include progressive muscle relaxation, simple breathing techniques, and guided imagery that focus on bodily and somatic relaxation. Adolescents randomized to Relaxation Therapy (RelaxT) will also receive exercises to do as homework in between sessions, parallel to the RF-CBT group.


Locations(3)

Nationwide Children's Hospital

Columbus, Ohio, United States

The Ohio State University

Columbus, Ohio, United States

University of Utah

Salt Lake City, Utah, United States

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NCT03859297


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