The Danish Warfarin-Dialysis Study - Safety and Efficacy of Warfarin in Patients With Atrial Fibrillation on Dialysis

This study is comparing the safety and effectiveness of warfarin (a traditional blood thinner) versus newer types of blood thinners (direct oral anticoagulants, or DOACs) in dialysis patients with atrial fibrillation (an irregular heartbeat), because the best treatment for this specific group of patients is currently unknown. **You may be eligible if...** - You are 18 or older - You are on chronic dialysis because your kidneys have failed (end-stage renal disease) - You have been diagnosed with atrial fibrillation (an irregular heartbeat), either ongoing or in episodes, confirmed by an ECG or heart monitor - You understand the study and can give written consent **You may NOT be eligible if...** - Your stroke risk score (CHA2DS2-VASc) is very low (score of 1 or less) - You have another reason requiring blood thinners (such as a mechanical heart valve, recent blood clot, or pulmonary embolism) - You are already on two antiplatelet (clot-preventing) drugs at the same time - You have had an active cancer or cancer treatment in the past year - You have had a recent stomach ulcer or digestive bleed, esophageal varices, or a genetic blood clotting disorder - You are lactose intolerant (due to excipients in the study medication) Talk to your doctor to see if this trial is right for you.