Correlation Study Between Clinical Phenotype and Pathology of Type 2 Diabetic Nephropathy
Chinese PLA General Hospital
2,000 participants
Nov 30, 2017
OBSERVATIONAL
Conditions
Summary
With the rapid increase of diabetic nephropathy worldwide, type 2 diabetes mellitus(DM) is the leading cause of end-stage renal disease(ESRD). Pathological types of diabetic kidney disease(DKD) could be mainly divided into diabetic nephropathy（DN）and non-diabetic renal diseases（NDRD）. There are no accurate renal biopsy indications and standardized operation procedures for type 2 diabetic nephropathy. The clinical stages of type 2 diabetic nephropathy still referred to the Mogensen stage of type 1 diabetic nephropathy. Thus, our study aim to clarify the differences in clinical phenotype between type 2 DN and type 2 NDRD, analysis the correlation between clinical and pathological features, and offer the criteria for clinical staging and prognosis.
Eligibility
Inclusion Criteria5
- Age≥18, male or female
- Clinical diagnosed as type 2 diabetes mellitus
- The presence of renal impairment including: microalbuminuria or overt proteinuria or renal insufficiency
- The renal biopsy was performed with complete renal pathological diagnosis
- Obtaining the signed informed consent from patients
Exclusion Criteria6
- The history of the disease was not complete
- Clinical diagnosed as other secondary renal diseases
- Patients with hereditary kidney disease
- Autoimmune diseases
- Patients with malignant tumor were expected to survive less than 6 months
- Pregnancy and lactation
Locations(1)
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NCT03865914