Insulin Regulation of Lipolysis and Lipolysis Proteins
Mayo Clinic
64 participants
Nov 12, 2018
INTERVENTIONAL
Conditions
Summary
These studies will define the abnormalities in the adipocyte proteins that are involved in the failure of insulin to suppress lipolysis normally in humans with upper body obesity and will help discover the mechanism by which pioglitazone, a medication used to treat type 2 diabetes and improve insulin resistance, improves insulin-regulation of adipocyte fatty acid metabolism.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Upper body obese subjects will undergo behavioral intervention with a life coach and a physical activity program of their choice for 4 months.
Upper body obese subjects will be block randomized to pioglitazone or placebo at enrollment.
Upper body obese subjects will complete a weight-stable period of 4 months and subsequently undergo behavioral intervention with a life coach and a physical activity program of their choice for 4 months.
Upper body obese subjects will be block randomized to pioglitazone or placebo at enrollment.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT03866408