RecruitingPhase 3NCT03902912

Effect of Prednisolone Treatment on Uterine Natural Killer Cells

Effect of Prednisolone Treatment on Uterine Natural Killer Cells and Endometrial Angiogenesis in Recurrent Miscarriage Around the Time of Embryo Implantation

Sponsor

Chinese University of Hong Kong

Enrollment

84 participants

Start Date

Jul 30, 2019

Study Type

INTERVENTIONAL

Conditions

Recurrent miscarriage

Summary

This study aims to investigate the role of uNK cells and the association with prednisolone.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 40 Years

Inclusion Criteria2

Women with a history of 3 or more consecutive miscarriages
Women younger than 40 years old

Exclusion Criteria7

Allergy to prednisolone
Women who have any uterine anomaly
Antiphospholipid syndrome
Hydrosalpinx
Thrombophilia
Abnormal thyroid function tests
women with diabetes,

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Interventions

DRUGPrednisolone

prednisolone oral 10 mg/day from day one of the subsequent menstrual cycle to day LH 7 of that cycle. Then, the participants will be given a tailing off dose of 5 mg/day for 3 days followed by 2 mg/day for 3 days and then 1 mg/day for 3 days.