RecruitingNCT06163092

Chronic Endometritis and Benefits of Antibiotics in Women With Recurrent Miscarriage

The Prevalence of Chronic Endometritis and Therapeutic Benefits of Antibiotics in Women With Unexplained Recurrent Miscarriage

Sponsor

Chinese University of Hong Kong

Enrollment

175 participants

Start Date

Apr 1, 2024

Study Type

OBSERVATIONAL

Conditions

Recurrent miscarriage

Summary

The aim of the study is to estimate the incidence of CE, evaluate the endometrial microorganism of CE, and investigate the therapeutic benefits of antibiotics for women with unexplained recurrent miscarriage and CE.

Eligibility

Sex: FEMALEMin Age: 20 YearsMax Age: 45 Years

Inclusion Criteria2

Women with a history of 2 or more consecutive miscarriages before 24 weeks of gestation
Women aged 20-45 years old

Exclusion Criteria11

Uncorrected uterine anomalies, such as the septate or bicornuate uterus, fibroids (submucous/intramural)
Untreated hydrosalpinx
Antiphospholipid syndrome
Known clinical autoimmune disease
Undergoing immunotherapy
Abnormal thyroid function
Abnormal karyotyping of couples
Known immunodeficiency pathologies such as diabetes or HIV
Currently taking other antibiotics or other trial medications or TCM;
Currently or previously involved in other clinical trials with medication intake;
Those with active pelvic inflammatory disease or suspicion of infection etc.

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Interventions

OTHER

If the CE is high, antibiotics will be given to the patients as usual practice in hospitals.

Locations(1)

The Chinese University of Hong Kong

Hong Kong, Hong Kong

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NCT06163092

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