RecruitingEarly Phase 1NCT03905603

Relative Contributions of Predictors of Hyperandrogenism in Older vs. Young Women With PCOS

Sponsor

University of Virginia

Enrollment

144 participants

Start Date

Oct 8, 2019

Study Type

INTERVENTIONAL

Conditions

Polycystic Ovary Syndrome

Summary

The objective of the study is to determine the relative contributions of four established predictors of hyperandrogenism (luteinizing hormone \[LH\] secretion, ovarian response to recombinant human chorionic gonadotropin \[r-hCG\] administration, adrenal response to adrenocorticotropic hormone \[ACTH\] administration, and hyperinsulinemia) in older vs. young women with Polycystic Ovary Syndrome (PCOS) in a cross-sectional, physiological study. The investigators hypothesize that hyperinsulinemia is a stronger independent predictor of free testosterone (T) in older reproductive aged (vs. young) women with PCOS.

Eligibility

Sex: FEMALEMin Age: 20 YearsMax Age: 49 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how male hormone (androgen) levels change as women with polycystic ovary syndrome (PCOS) age, comparing younger women (ages 20-30) to older women (ages 40-49) with the same condition. **You may be eligible if...** - You are a woman aged 20-30 or 40-49 - You have PCOS with signs of high male hormones (such as excess body hair or acne) plus irregular or infrequent periods - Your screening lab results are within acceptable ranges **You may NOT be eligible if...** - You do not meet the PCOS diagnostic criteria - Your lab results show significant abnormalities unrelated to PCOS or obesity Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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