RecruitingNCT03929887

KOrea Renal Biobank NEtwoRk System TOward NExt-generation Analysis

Multicenter Prospective Cohort of Kidney Biopsy for Glomerular Disease Research


Sponsor

Seoul National University Hospital

Enrollment

3,000 participants

Start Date

May 1, 2019

Study Type

OBSERVATIONAL

Conditions

Summary

Glomerulonephritis (GN) generates an enormous individual and social economic burden. However, the therapeutic options are largely based on clinical and pathological parameters and the individual response to therapy or prognosis is uncertain. Recently, along with advances in molecular analysis and computational bioinformatics, genomic data from human renal biopsies could provide a strong foundation for the future of precision medicine in nephrology. In response to a request for applications by the Ministry of Health and Welfare of Korea for the creation of Clinical Research Registry, multi-center N network has been established for prospective cohort with kidney biopsy samples (KORNERSTONE). Through this Network the investigators hope to understand the fundamental biology of glomerulonephritis and aim to bank long-term observational data and corresponding biological data including genomic data from kidney tissues, and kidney pathologic data which is digitalized This database is archived to a web-based platform to access easily and further enrich for researchers.


Eligibility

Inclusion Criteria2

  • Patient suspected of glomerular disease who received kidney biopsy in participating university medical centers
  • Children (age\<18 years) also included

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Interventions

OTHERKidney Biopsy

Patients scheduled to undergo a clinically indicated kidney biopsy will be requested to consent to an additional renal core and various patient-derived samples.


Locations(6)

KangWon National University Hospital

Chuncheon, South Korea

Keimyung University Dongsan Medical Center

Daegu, South Korea

Chung-Ang University Hosptial

Seoul, South Korea

Seoul National University Hospital

Seoul, South Korea

Severance Hospital

Seoul, South Korea

SMG-SNU Boramae Medical Center

Seoul, South Korea

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NCT03929887


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