RecruitingNCT03929887

KOrea Renal Biobank NEtwoRk System TOward NExt-generation Analysis

Multicenter Prospective Cohort of Kidney Biopsy for Glomerular Disease Research

Sponsor

Seoul National University Hospital

Enrollment

3,000 participants

Start Date

May 1, 2019

Study Type

OBSERVATIONAL

Conditions

Focal Segmental Glomerulosclerosis IgA Nephropathy Membranous Nephropathy Lupus Nephritis Glomerular Disease Minimal Change Disease Crescentic Glomerulonephritis

Summary

Glomerulonephritis (GN) generates an enormous individual and social economic burden. However, the therapeutic options are largely based on clinical and pathological parameters and the individual response to therapy or prognosis is uncertain. Recently, along with advances in molecular analysis and computational bioinformatics, genomic data from human renal biopsies could provide a strong foundation for the future of precision medicine in nephrology. In response to a request for applications by the Ministry of Health and Welfare of Korea for the creation of Clinical Research Registry, multi-center N network has been established for prospective cohort with kidney biopsy samples (KORNERSTONE). Through this Network the investigators hope to understand the fundamental biology of glomerulonephritis and aim to bank long-term observational data and corresponding biological data including genomic data from kidney tissues, and kidney pathologic data which is digitalized This database is archived to a web-based platform to access easily and further enrich for researchers.

Eligibility

Plain Language Summary

Simplified for easier understanding

This clinical trial, titled "KOrea Renal Biobank NEtwoRk System TOward NExt-generation Analysis" (study ID: NCT03929887), is a biobank registry in South Korea collecting kidney tissue, blood, and clinical data from patients who undergo kidney biopsy to evaluate suspected glomerular disease — conditions where the filtering units of the kidney (glomeruli) become damaged. By building a large-scale biobank, researchers aim to advance understanding of kidney diseases using next-generation genomic and molecular analysis tools. The study is open to both adults and children (under 18) who are suspected to have a glomerular disease and undergo kidney biopsy at participating Korean university medical centers. The only exclusion criterion is having previously received a kidney transplant. You may be eligible if you: - Are suspected of having a glomerular kidney disease - Are scheduled to undergo a kidney biopsy at a participating center - Are of any age (children are also eligible) You may NOT be eligible if you: - Have previously received a kidney transplant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERKidney Biopsy

Patients scheduled to undergo a clinically indicated kidney biopsy will be requested to consent to an additional renal core and various patient-derived samples.