RecruitingNCT03953014

Pharmacogenetics of Antidepressant-Induced Disinhibition

Pharmacogenetics of Antidepressant-Induced Disinhibition in Children Study


Sponsor

University of Calgary

Enrollment

120 participants

Start Date

Jan 2, 2019

Study Type

OBSERVATIONAL

Conditions

Summary

The purpose of this study is to identify pharmacogenetic profiles associated with selective serotonin reuptake inhibitors (SSRI)-induced behavioral disinhibition in children with Major depressive disorder (MDD), anxiety disorders and/or obsessive-compulsive disorder (OCD) that could be used clinically to reduce the incidence of this adverse event and improve health outcomes.


Eligibility

Min Age: 6 YearsMax Age: 17 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how a person's genes influence side effects from antidepressants — specifically a problem called "disinhibition," which can include increased impulsivity, agitation, or mood swings, especially in young people taking SSRIs. Researchers are reviewing medical records to identify genetic patterns linked to these reactions. **You may be eligible if...** - You are between 6 and 24 years old - Your medical records are available for review - You have a diagnosis of major depressive disorder, anxiety disorder, or OCD - You have a current or past history of taking an SSRI antidepressant **You may NOT be eligible if...** - Your parent or legal guardian cannot give consent - You are unable to give your own assent (agreement to participate) - Your medical records are not accessible or complete enough for review Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Child and Adolescent Addiction, Mental Health & Psychiatry

Calgary, Alberta, Canada

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NCT03953014


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