Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma

This study is exploring less invasive ways — such as a swallowable capsule sponge — to detect Barrett's esophagus and esophageal cancer, as an alternative to traditional endoscopy. **You may be eligible if...** - You are age 50–85 with three or more risk factors for Barrett's esophagus, including acid reflux, obesity (BMI 30+), or long-term acid-reducing medication use (Aim 1) - OR you are age 18–90 with a known or suspected Barrett's esophagus segment of at least 1 cm and are scheduled for a routine endoscopy (Aim 2 and 3) - OR you are having a clinically indicated endoscopy without known Barrett's (as a comparison group) **You may NOT be eligible if...** - You have a history of esophageal cancer, prior ablation therapy for Barrett's, esophageal varices, or cirrhosis - You take blood thinners like Warfarin - You have had an endoscopy within the past 5 years (for Aim 1) - You have active Barrett's esophagus with a history of ablation (for Aim 2) Talk to your doctor to see if this trial is right for you.