Barrett Esophagus Clinical Trials

24 recruiting

Barrett Esophagus Trials at a Glance

24 actively recruiting trials for barrett esophagus are listed on ClinicalTrialsFinder across 6 cities in 8 countries. The largest study group is Not Applicable with 12 trials, with the heaviest enrollment activity in Aurora, Rochester, and Chapel Hill. Lead sponsors running barrett esophagus studies include University of Colorado, Denver, Mayo Clinic, and Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA).

Browse barrett esophagus trials by phase

Treatments under study

About Barrett Esophagus Clinical Trials

Looking for clinical trials for Barrett Esophagus? There are currently 24 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Barrett Esophagus trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Barrett Esophagus clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 24 trials

Recruiting
Phase 2

Obeticholic Acid for Prevention in Barrett's Esophagus

Esophageal AdenocarcinomaBarrett Esophagus
National Cancer Institute (NCI)30 enrolled8 locationsNCT04939051
Recruiting

Impact of RFA on Esophageal Distensibility and Mucosal Impedance

Barrett EsophagusRadiofrequency AblationDysplastic Barrett's Esophagus
Mayo Clinic10 enrolled1 locationNCT07126535
Recruiting

Clinical Utility of WATS3D: A 5-Year Prospective Study

Barrett EsophagusEsophageal DiseasesGastro Esophageal Reflux+1 more
CDx Diagnostics90,000 enrolled1 locationNCT04312633
Recruiting

Non-Endoscopic Detection of Barrett's Esophagus Using Methylation Biomarkers on EndoSign® Cell Collection Device Samples

Barrett Esophagus
Cyted Health Inc700 enrolled1 locationNCT06803927
Recruiting
Not Applicable

Molecular Assessment for Gastro-Esophageal Cancer

Esophageal CancerGastric CancerBarrett Esophagus
KU Leuven1,000 enrolled1 locationNCT06346054
Recruiting

Endoscopic Submucosal Dissection (ESD)

Barrett EsophagusEsophageal LesionGastrointestinal Lesions
AdventHealth1,000 enrolled1 locationNCT05468008
Recruiting
Not Applicable

Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma

Esophageal AdenocarcinomaBarrett Esophagus
Mayo Clinic1,550 enrolled9 locationsNCT03961945
Recruiting

EsophaCap for the Detection of Early Esophageal Carcinoma

Esophageal CancerGastric CancerBarrett Esophagus
Johns Hopkins University2,500 enrolled2 locationsNCT04214119
Recruiting
Not Applicable

Assessment of a Minimally Invasive Collection Device for Molecular Analysis of Esophageal Samples

Esophageal AdenocarcinomaBarrett EsophagusBarretts Esophagus With Dysplasia+1 more
Mayo Clinic400 enrolled5 locationsNCT06071845
Recruiting

Barrett's Esophagitis in Anorexia Nervosa Binge/Purge Subtype

Esophageal AdenocarcinomaBarrett EsophagusEating Disorders+3 more
Denver Health and Hospital Authority25 enrolled3 locationsNCT06532734
Recruiting
Not Applicable

Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia

Esophageal AdenocarcinomaBarrett EsophagusBarretts Esophagus With Dysplasia
University of Colorado, Denver680 enrolled23 locationsNCT05753748
Recruiting
Not Applicable

Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

Esophageal AdenocarcinomaBarrett EsophagusGastroesophageal Reflux
Case Comprehensive Cancer Center800 enrolled5 locationsNCT06687603
Recruiting
Not Applicable

Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett's Esophagus

Barrett Esophagus
Massachusetts General Hospital30 enrolled1 locationNCT03830801
Recruiting

"Less-is-more in Barrett-surveillance" Care Evaluation of Barrett's Patients With Low-Risk in Whom Endoscopic Surveillance is Stopped. The BLISS Project.

Barrett EsophagusBarrett Esophagus Adenocarcinoma
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)3,156 enrolled1 locationNCT06803147
Recruiting
Not Applicable

Ultralong-segment Barrett's Esophagus: Towards a Capsule-sponge Surveillance Strategy

Barrett Esophagus
Erasmus Medical Center137 enrolled1 locationNCT06720636
Recruiting

InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer

Lung CancerCancer RiskCancer Predisposition Syndrome+28 more
Dana-Farber Cancer Institute5,000 enrolled1 locationNCT05463796
Recruiting
Not Applicable

Nonendoscopic Screening for Barrett's Esophagus in Veterans Without Chronic Reflux

Barrett EsophagusObese PatientsTobacco Use+2 more
Louis Stokes VA Medical Center400 enrolled1 locationNCT06746623
Recruiting

Longitudinal Oral Microbiome Sampling for BE

Barrett Esophagus
Columbia University275 enrolled2 locationsNCT05133102
Recruiting

Patient Preferences for Barrett's Esophagus and Esophageal Cancer Screening Tests

Barrett EsophagusGastro Esophageal Reflux Disease
University of Colorado, Denver556 enrolled1 locationNCT06693622
Recruiting
Not Applicable

Prospective Endoscopic Follow-up of Patients With Submucosal and High Risk Mucosal Esophageal Adenocarcinoma

Barrett EsophagusSubmucosal Esophageal AdenocarcinomaHigh-risk Mucosal Esophageal Adenocarcinoma
Amsterdam UMC225 enrolled20 locationsNCT03222635