Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal Metastases

This study is testing a specialized lung treatment called pulmonary suffusion — a technique that delivers cancer-fighting drugs directly into the lungs in high concentrations via a catheter system — for patients with cancer that has spread to the lungs from soft tissue sarcoma, bone sarcoma, or colorectal cancer. The goal is to control remaining cancer cells after surgery or other treatments. **You may be eligible if...** - You have lung metastases from soft tissue sarcoma, osteosarcoma, or colorectal cancer - You are in adequate physical condition (ECOG performance status 2 or less) - Your blood counts and organ function are adequate - You are willing to undergo the suffusion procedure **You may NOT be eligible if...** - Your cancer has spread to other organs beyond the lungs in an uncontrolled way - You have severe breathing problems or lung disease that makes this procedure unsafe - You have had recent major surgery - You are pregnant or breastfeeding - You have very poor blood counts Talk to your doctor to see if this trial is right for you.