RecruitingPhase 2NCT03970720

Restoration of Hypoglycemia Awareness With Metoclopramide


Sponsor

Simon Fisher

Enrollment

36 participants

Start Date

May 28, 2019

Study Type

INTERVENTIONAL

Conditions

Summary

Metoclopramide is a drug approved by the FDA for gastroesophageal reflux and to relieve symptoms in adults with acute and recurrent diabetic gastroparesis. The objective of this study is to determine whether metoclopramide can improve hypoglycemia awareness and decrease the incidence of hypoglycemia in type 1 diabetes patients with hypoglycemia unawareness.


Eligibility

Min Age: 20 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether a drug called metoclopramide (commonly used for nausea) can help people with Type 1 diabetes recognize when their blood sugar is dropping too low — a problem called hypoglycemia unawareness. Some people with long-standing Type 1 diabetes lose the ability to feel warning signs of low blood sugar. **You may be eligible if...** - You have Type 1 diabetes for more than 5 years - Your HbA1c (3-month blood sugar average) is 9% or below - You are able to give informed consent **You may NOT be eligible if...** - You have a history of heart attack, heart rhythm problems, heart failure, or stroke - You have advanced liver disease or active anemia - You are pregnant, breastfeeding, or unable to use effective contraception - You have uncontrolled mania or major depression - You have had a previous allergic reaction to heparin or metoclopramide Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGMetoclopramide

10 mg metoclopramide four times a day

DRUGPlacebo

10 mg matching placebo capsules four times a day


Locations(2)

University of Kentucky

Lexington, Kentucky, United States

University of Utah

Salt Lake City, Utah, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT03970720


Related Trials