Surgery and Niraparib in Secondary Recurrent Ovarian Cancer (SOC-3 Trial)
A Phase II, Randomized Study of Cytoreductive Surgery Combined With Niraparib Maintenance in Platinum-sensitive, Secondary Recurrent Ovarian Cancer
Shanghai Gynecologic Oncology Group
167 participants
Oct 18, 2019
INTERVENTIONAL
Conditions
Summary
This is a Phase II, open-label, multicenter, randomized umbrella study to evaluate the efficacy of cytoreductive surgery and Niraparib maintenance in participants with platinum-sensitive secondary recurrent ovarian cancer. Cohort 1 will focus on participants without prior use of PARP inhibitor, and without prior secondary cytoreduction (SCR) when first recurrence. Cohort 2 will focus on participants with prior use of PARP inhibitor, but without prior SCR when first recurrence. Cohort 3 will focus on participants with SCR when first recurrence, but without prior use of PARP inhibitor.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
Tumor debulking surgery (surgery in recurrent ovarian disease)
Salvage chemotherapy
Niraparib maintenance therapy
Locations(5)
View Full Details on ClinicalTrials.gov
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NCT03983226