RecruitingNot ApplicableNCT03990909

Pilot Study of BCAA on Sleep

A Pilot Study of Dietary Supplementation With Branched Chain Amino Acids on Sleep


Sponsor

Portland VA Medical Center

Enrollment

300 participants

Start Date

Mar 1, 2019

Study Type

INTERVENTIONAL

Conditions

Summary

Individuals will be recruited from the VA Portland Health Care System and the community affiliated with Oregon Health \& Science University. Traumatic brain injury status will be assessed as a contributing factor. Subjects will be randomized to one of 3 groups (BCAA or one of 2 placebo conditions) and instructed to consume study product twice daily for 21 days. Self-report questionnaires, wrist actigraphy, pressure pain testing, and cognitive function will be assessed pre and post the experimental period.


Eligibility

Min Age: 18 YearsMax Age: 89 Years

Inclusion Criteria4

  • Veteran
  • English Speaking
  • Accessible via phone
  • Sleep problems

Exclusion Criteria5

  • Decisional impairment
  • Nickel allergy
  • Maple syrup urine disease or family history of disease
  • Allergy to sucralose
  • Currently taking BCAAs

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Interventions

DIETARY_SUPPLEMENTBranched Chain Amino Acids

60 grams of BCAA (2:1:1 ratio of Leucine:Isoleucine:Valine) consumed in two doses (30 grams each) mixed into 20 oz of water for up to21days (42 total drinks).

DIETARY_SUPPLEMENTRice Protein

60 grams of rice protein consumed in two doses (30 grams each) mixed into 20 oz of water for up to 21days (42 total drinks).

DIETARY_SUPPLEMENTMicrocrystalline Cellulose

60 grams of microcrystalline cellulose, consumed in two doses (30 grams each) mixed into 20 oz of water for up to 21days (42 total drinks).


Locations(1)

VA Portland Health Care System

Portland, Oregon, United States

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NCT03990909


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