RecruitingPhase 1Phase 2NCT03255408

Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia

Role of Cerebral Blood Flow on Ventilatory Stability During Sleep in Normoxia and Intermittent Hypoxia

Sponsor

University of Calgary

Enrollment

12 participants

Start Date

Jan 1, 2023

Study Type

INTERVENTIONAL

Conditions

Hypoxia, Brain Blood Pressure Stroke Endothelial Dysfunction Sleep Disorder Sleep Apnea Oxidative Stress Obstructive Sleep Apnea of Adult

Summary

A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).

Eligibility

Min Age: 18 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Drug Lowering CBF and Intermittent Hypoxia Sleep, Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep, and others for people with blood pressure, endothelial dysfunction, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years to 45 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDrug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep

The study participants will take Cerebral Blood Flow (CBF) lowering drug and sleep under Normoxia Exposure

DRUGDrug Lowering CBF and Intermittent Hypoxia Sleep

The study participants will take Cerebral Blood Flow (CBF) lowering drug and sleep under Intermittent Hypoxia (IH) Exposure

DRUGPlacebo and Normoxia Sleep

The study participants will take Placebo and sleep under Normoxia Exposure

DRUGPlacebo and Intermittent Hypoxia Sleep

The study participants will take Placebo and sleep under Intermittent Hypoxia (IH) Exposure

Locations(1)

University of Calgary

Calgary, Alberta, Canada

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NCT03255408

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