Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
Role of Cerebral Blood Flow on Ventilatory Stability During Sleep in Normoxia and Intermittent Hypoxia
University of Calgary
12 participants
Jan 1, 2023
INTERVENTIONAL
Conditions
Summary
A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).
Eligibility
Inclusion Criteria5
- Healthy adults
- - 45 years of age
- Living in Calgary for the past one year
- Have no medical condition or should not be taking any blood pressure medications.
- The participant should not be lactose intolerant
Exclusion Criteria5
- Cerebrovascular, cardio-respiratory, renal and metabolic diseases
- Bleeding disorders and upper gastrointestinal diseases e.g. peptic ulcer disease
- Pregnancy, obese and sleep-disordered breathing
- Drug allergies to non-steroidal anti-inflammatories
- Currently smoking
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Interventions
The study participants will take Cerebral Blood Flow (CBF) lowering drug and sleep under Normoxia Exposure
The study participants will take Cerebral Blood Flow (CBF) lowering drug and sleep under Intermittent Hypoxia (IH) Exposure
The study participants will take Placebo and sleep under Normoxia Exposure
The study participants will take Placebo and sleep under Intermittent Hypoxia (IH) Exposure
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT03255408