Targeted Pathway Inhibition in Patients With Pancreatic Cancer

This study is testing several targeted therapy drugs for people with pancreatic cancer at various stages — from potentially operable tumors to metastatic disease. The goal is to match patients to specific drugs based on their cancer's genetic and molecular profile. **You may be eligible if...** - You are 18 or older - You have a confirmed or clinically suspected diagnosis of pancreatic adenocarcinoma (any stage: resectable, borderline resectable, locally advanced, or metastatic) - You are in adequate health to receive treatment (ECOG 0–2) - You have measurable disease on imaging - If you received prior treatment, at least 10 days have passed since your last therapy **You may NOT be eligible if...** - Your organ function does not meet minimum thresholds - You have unresolved side effects from prior cancer therapy - You have certain genetic or medical conditions that would conflict with specific study arms - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.