RecruitingNot ApplicableNCT04043598

Crystalloid Fluid Choice and Neurological Outcome in Patients After Subarachnoid Haemorrhage

Crystalloid Fluid Choice and Neurological Outcome in Patients After Subarachnoid Haemorrhage - a Multi-center Randomized Double-blind Clinical Trial


Sponsor

Insel Gruppe AG, University Hospital Bern

Enrollment

320 participants

Start Date

May 24, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

Patients with subarachnoid hemorrhage are prone to suffer from dysnatriemia. Evidence shows that hyponatriemia is associated with increased incidence of vasospasm, brain swelling and mortality in these patients. Patients with subarachnoid hemorrhage often require large amounts of iv fluids in order to maintain euvolemia and support cardiocirculatory function. Prior evidence shows that the type of infusion fluid significantly influences blood sodium content. Hence, this study evaluated whether the sodium content of the infusion solution impacts mortality and morbidity in patients with subarachnoid hemorrhage.


Eligibility

Min Age: 16 Years

Inclusion Criteria1

  • All adult patients suffering from non-traumatic subarachnoid haemorrhage.

Exclusion Criteria5

  • Patients with major intra-cranial trauma
  • Diagnosis of an AV-malformation as the source of subarachnoid hemorrhage on the primary CT/MRI or angiography
  • More than 24 hours after diagnosis of subarachnoid haemorrhage as diagnosed by cerebral imaging (CT scan or MRI)
  • Patients with clear limitation to therapy at hospital admission (eg ICU admission for evaluation of organ donation)
  • Declining of informed consent

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Interventions

DRUG0.9% Sodium-chloride

We will compare two already established treatment protocols: the use of normal saline versus lactated Ringer's for fluid therapy in patients with subarachnoid hemorrhage.

DRUGRinger's Lactate

We will compare two already established treatment protocols: the use of normal saline versus lactated Ringer's for fluid therapy in patients with subarachnoid hemorrhage.


Locations(3)

Department of perioperative Intensive Care Medicine

Sankt Gallen, Canton of St. Gallen, Switzerland

Department of Intensive Care, Bern University Hospital and University of Bern, Bern, Switzerland

Bern, Switzerland

Department of Intensive Care Medicine

Geneva, Switzerland

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NCT04043598


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