Critical Illness Clinical Trials

212 recruitingLast updated: July 17, 2026

There are 212 actively recruiting critical illness clinical trials across 42 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4, Phase 1, Early Phase 1. Top locations include Melbourne, Victoria, Australia, Kingston, Ontario, Canada, Beijing, Beijing Municipality, China. Updated daily from ClinicalTrials.gov.


Critical Illness Trials at a Glance

212 actively recruiting trials for critical illness are listed on ClinicalTrialsFinder across 6 cities in 42 countries. The largest study group is Not Applicable with 86 trials, with the heaviest enrollment activity in Melbourne, Kingston, and Beijing. Lead sponsors running critical illness studies include Australian and New Zealand Intensive Care Research Centre, Duke University, and National Taiwan University Hospital.

Browse critical illness trials by phase

Treatments under study

About Critical Illness Clinical Trials

Looking for clinical trials for Critical Illness? There are currently 222 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Critical Illness trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Critical Illness clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 212 trials

Recruiting
Phase 1Phase 2

PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia

Critical IllnessBronchopulmonary Dysplasia (BPD)Premature Births
Duke University28 enrolled5 locationsNCT07101640
Recruiting
Not Applicable

MyokinE100 System: Closed Loop Electrical Muscle Stimulation to Mitigate ICU Acquired Weakness in Medical ICU Patients

ICU acquired weaknessSarcopeniaSepsis+4 more
Health Discovery Labs50 enrolled3 locationsNCT07362862
Recruiting
Not Applicable

The Effects of Endotracheal Suctioning on Pain and Serum Markers

SepsisAdultPneumonia+12 more
Loma Linda University110 enrolled1 locationNCT06692400
Recruiting
Not Applicable

COMPARE-VENT Feasibility Pilot Study

Cardiogenic ShockMechanical VentilationCritical Illness+4 more
Mayo Clinic75 enrolled1 locationNCT07656259
Recruiting

Volume Removal Intolerance During Net Ultrafiltration in Acute Kidney Injury Patients

Acute Kidney InjuryCritical IllnessRenal Replacement Therapy for Acute Kidney Injury in ICU+2 more
Hospital Las Higueras128 enrolled10 locationsNCT07643597
Recruiting

Pervasive Sensing and AI in Intelligent ICU

ConfusionPainDelirium+1 more
University of Florida400 enrolled1 locationNCT05127265
Recruiting

Digital and Plasma Biomarkers in Delirium

Sleep QualityCritical IllnessDelirium in the Intensive Care Unit
Scripps Health100 enrolled2 locationsNCT07694206
Recruiting

Intensive Care Outcome Prediction Using Admission Carbohydrate-deficient Transferrin

Critical IllnessAlcohol MisuseIntensive Care (ICU)
Medical University of Vienna800 enrolled1 locationNCT07632716
Recruiting
Not Applicable

Real-Time Algorithm-Driven Ventilation Feedback to Improve Lung-Protective Ventilation in Patients With ARDS (REALVENT-study)

Respiratory FailureCritical IllnessARDS (Acute Respiratory Distress Syndrome)+1 more
Peking Union Medical College Hospital208 enrolled1 locationNCT07307066
Recruiting

Muscle Recovery After Critical Illness

ICU acquired weaknessMuscle WeaknessCritical Illness+1 more
Esther Dupont-Versteegden209 enrolled3 locationsNCT05537298
Recruiting

Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients

Acute Respiratory FailureCritical Illness
The Institute of Molecular and Translational Medicine, Czech Republic200 enrolled2 locationsNCT06189924
Recruiting
Not Applicable

Improving Psychological Outcomes for Acute Respiratory Failure Survivors Using a Self-Management Intervention

AnxietyRespiratory FailureCritical Illness
Johns Hopkins University60 enrolled1 locationNCT06341972
Recruiting
Not Applicable

Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients

Anxiety AcuteDelirium in the Intensive Care UnitSleep Quality in Adult ICU Patients+1 more
Milton S. Hershey Medical Center30 enrolled1 locationNCT07649876
Recruiting

Mechanical Insufflation-Exsufflation in Critically Ill Patients

Airway ClearanceCritical IllnessCritical Care+5 more
Medipol University30 enrolled4 locationsNCT07420946
Recruiting

Evaluating the Unmet Needs of Older Adults to Promote Functional Recovery After a Critical Illness

Critical IllnessIllness, Critical
Yale University350 enrolled1 locationNCT06006000
Recruiting
Phase 4

Efficacy and Safety of Remimazolam Besylate for Sedation in Post-Non-Cardiac Surgery Patients Requiring Mechanical Ventilation

SurgeryMechanical Ventilation ComplicationCritical Illness+3 more
Beijing Shijitan Hospital, Capital Medical University306 enrolled1 locationNCT06575530
Recruiting

Hemodynamic Effects of Norepinephrine Reduction on Critical Closing Pressure in Distributive Shock

Critical IllnessDistributive shockHemodynamic Assessment
Peking Union Medical College Hospital30 enrolled1 locationNCT07653659
Recruiting

ICU Combined Assessment of Cardio-Respiratory Exercise

ICU acquired weaknessmicrocirculationSepsis+2 more
University of Manitoba50 enrolled2 locationsNCT06193980
Recruiting
Phase 2

Exogenous Ketone Supplementation in ICU Delirium

ICU deliriumCritical Illness
Vanderbilt University Medical Center40 enrolled1 locationNCT07364162
Recruiting
Not Applicable

Preoperative Fasting vs. Not Fasting in Critically Ill Patients

Pulmonary aspirationSurgical Procedure, UnspecifiedCritical Illness+1 more
Massachusetts General Hospital1,072 enrolled19 locationsNCT06751043