Critical Illness Clinical Trials

204 recruitingLast updated: June 18, 2026

There are 204 actively recruiting critical illness clinical trials across 40 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4, Phase 1, Early Phase 1. Top locations include Melbourne, Victoria, Australia, Baltimore, Maryland, United States, Columbus, Ohio, United States. Updated daily from ClinicalTrials.gov.


Critical Illness Trials at a Glance

204 actively recruiting trials for critical illness are listed on ClinicalTrialsFinder across 6 cities in 40 countries. The largest study group is Not Applicable with 83 trials, with the heaviest enrollment activity in Melbourne, Baltimore, and Columbus. Lead sponsors running critical illness studies include Australian and New Zealand Intensive Care Research Centre, Duke University, and National Taiwan University Hospital.

Browse critical illness trials by phase

Treatments under study

About Critical Illness Clinical Trials

Looking for clinical trials for Critical Illness? There are currently 215 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Critical Illness trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Critical Illness clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 204 trials

Recruiting

ICU Combined Assessment of Cardio-Respiratory Exercise

ICU acquired weaknessmicrocirculationSepsis+2 more
University of Manitoba50 enrolled2 locationsNCT06193980
Recruiting
Phase 2

Exogenous Ketone Supplementation in ICU Delirium

ICU deliriumCritical Illness
Vanderbilt University Medical Center40 enrolled1 locationNCT07364162
Recruiting
Not Applicable

Preoperative Fasting vs. Not Fasting in Critically Ill Patients

Pulmonary aspirationSurgical Procedure, UnspecifiedCritical Illness+1 more
Massachusetts General Hospital1,072 enrolled19 locationsNCT06751043
Recruiting
Not Applicable

Effectiveness of a Structured Multidimensional Tele-rehabilitation Intervention in Cardiac Patients With Post-Intensive Care Syndrome (CARDIO-PICS)

Critical IllnessPost Intensive Care Syndrome (PICS)Cardiopathy
Fondazione Don Carlo Gnocchi Onlus326 enrolled1 locationNCT07599306
Recruiting

Muscle Recovery After Critical Illness

ICU acquired weaknessMuscle WeaknessCritical Illness+1 more
Kirby Mayer209 enrolled3 locationsNCT05537298
Recruiting
Phase 1Phase 2

PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia

Critical IllnessBronchopulmonary Dysplasia (BPD)Premature Births
Duke University28 enrolled5 locationsNCT07101640
Recruiting
Not Applicable

Optimizing Recovery in Trauma Patients by Integrating Enhanced Nutrition Delivery

Critical IllnessTrauma
Duke University60 enrolled1 locationNCT06521086
Recruiting

Effect of Protein Dosage on Persistent Acute Renal Failure in Critically Ill Patients.

Critical IllnessAcute Kidney FailureNutritional Support+2 more
Hospital Italiano de Buenos Aires344 enrolled6 locationsNCT07631221
Recruiting
Not Applicable

Pharmacological Reversal of Neuromuscular Blockade in Critically Ill Patients

Critical IllnessNeuromuscular BlockadeNeurologic Findings
Seoul National University Hospital30 enrolled1 locationNCT05993390
Recruiting
Not Applicable

REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19

Cardiorespiratory FitnessICU acquired weaknessCOVID-19+2 more
Duke University120 enrolled5 locationsNCT05218083
Recruiting

NIBP Validation Study

Critical Illness
Philips Clinical & Medical Affairs Global189 enrolled5 locationsNCT05673408
Recruiting
Not Applicable

Feasibility of Light Therapy in the Pediatric Intensive Care Unit (ICU)

Circadian DysregulationLight ExposurePediatric Critical Illness
Laura Beth Kalvas30 enrolled1 locationNCT07384585
Recruiting
Early Phase 1

iNO300 Therapy in Critically Ill Patients With Pneumonia

PneumoniaCritical Illness
Massachusetts General Hospital34 enrolled1 locationNCT06950294
Recruiting

Peripheral pULSe Assessment and Arterial pRessure (PULSAR)

Critical IllnessHypotensionShock+2 more
Region Stockholm5,000 enrolled1 locationNCT07609095
Recruiting
Not Applicable

Reestablishing Sleep and Circadian Alignment in Medical Intensive Care Unit (MICU) Patients Via a Mechanistic RCT of an Sleep Chronobundle

Critical IllnessSleep DeprivationCircadian Rhythm Sleep Disorder, Unspecified
Yale University160 enrolled2 locationsNCT05551325
Recruiting
Not Applicable

Trial on the Impact of Indirect Calorimetry-Guided Nutritional Support on Patient-Centered Outcomes in Critically Ill Patients - The OPTICal Study

Critical IllnessICU
HEIDEGGER CP356 enrolled3 locationsNCT07343440
Recruiting
Not Applicable

MyokinE100 System: Closed Loop Electrical Muscle Stimulation to Mitigate ICU Acquired Weakness in Medical ICU Patients

ICU acquired weaknessSarcopeniaSepsis+4 more
Health Discovery Labs50 enrolled3 locationsNCT07362862
Recruiting

Prognostic Value of Novel Biomarkers on Adverse Renal Outcomes in High-Risk Cardiac Surgery Patients

Cardiac Surgery associated Acute kidney injuryCritical Illness
Guowei Tu1,491 enrolled2 locationsNCT07418242
Recruiting
Phase 3

RECOMMEND Platform Trial

Intensive Care MedicineCritical IllnessCardiac Arrest (CA)+2 more
Australian and New Zealand Intensive Care Research Centre600 enrolled3 locationsNCT06526533
Recruiting
Not Applicable

Virtual Reality for Recovery After Intensive Care (PICS)

Cognitive ImpairmentCritical IllnessCritical Illness Recovery+4 more
University of Minho51 enrolled1 locationNCT07585500