Critical Illness Clinical Trials

190 recruiting

Critical Illness Trials at a Glance

177 actively recruiting trials for critical illness are listed on ClinicalTrialsFinder across 6 cities in 38 countries. The largest study group is Not Applicable with 70 trials, with the heaviest enrollment activity in Melbourne, Columbus, and Taipei. Lead sponsors running critical illness studies include National Taiwan University Hospital, Duke University, and Australian and New Zealand Intensive Care Research Centre.

Browse critical illness trials by phase

Treatments under study

About Critical Illness Clinical Trials

Looking for clinical trials for Critical Illness? There are currently 190 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Critical Illness trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Critical Illness clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 177 trials

Recruiting
Not Applicable

Crystalloid Fluid Choice and Neurological Outcome in Patients After Subarachnoid Haemorrhage

Critical IllnessSubarachnoid HemorrhageInfusion Fluid+1 more
Insel Gruppe AG, University Hospital Bern320 enrolled3 locationsNCT04043598
Recruiting
Phase 4

Effect of Protocolized Magnesium Replacement on Mortality and Atrial Fibrillation in Critically Ill Patients

Critical Illness
Scarborough General Hospital3,253 enrolled6 locationsNCT07173855
Recruiting
Not Applicable

"PROTECT-ICU: Impact of an Educational Intervention

Critical IllnessPost Intensive Care Syndrome (PICS)
Carola Giménez-Esparza Vich900 enrolled2 locationsNCT07542613
Recruiting

Comparison of the Efficacy and Safety of Ciprofol Versus Propofol for Sedation in ICU Patients Undergoing Non-Invasive Ventilation

Respiratory FailureCritical Illness
Nanfang Hospital, Southern Medical University1,680 enrolled1 locationNCT07536750
Recruiting

The Feasibility of Pulmonary Perfusion Assessment Using Sodium Bicarbonate Contrast With Electrical Impedance Tomography: A Prospective Pilot Study

Acute Respiratory Distress Syndrome (ARDS)Acute Respiratory FailurePneumonia+2 more
First Affiliated Hospital of Wannan Medical College41 enrolled1 locationNCT07542366
Recruiting

Assessment of Stroke Volume in Shock Using Echocardiography Versus Bioreactive Impedance

Critical IllnessShock
University of Nevada, Las Vegas30 enrolled1 locationNCT07020637
Recruiting

UP STUDY - Decipher Persistent Critical Illness Through in Deep Clinical Phenotyping.

Critical IllnessCritical CareCritical Care, Intensive Care+2 more
Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa7,000 enrolled7 locationsNCT07510776
Recruiting

Asia Pediatric Intensive Care Epidemiology and Outcomes Study

PediatricsCritical IllnessIntensive Care Unit
KK Women's and Children's Hospital10,000 enrolled2 locationsNCT06481644
Recruiting

Predictive Value of Gastrointestinal Blood Flow for Enteral Nutrition Intolerance in Critically Ill Patients

Critical IllnessEnteral Nutrition FeedingMachine Learning+2 more
Ruijin Hospital500 enrolled1 locationNCT07521111
Recruiting
Not Applicable

Medical Honey for Wound Treatment in Intensive Care. (MICARéa) Randomized, Controlled, Single-center Pilot Study.

Wound HealCritical Illness
University Hospital, Angers60 enrolled1 locationNCT06150326
Recruiting
Not Applicable

Feasibility of Light Therapy in the Pediatric Intensive Care Unit (ICU)

Circadian DysregulationLight ExposurePediatric Critical Illness
Laura Beth Kalvas30 enrolled1 locationNCT07384585
Recruiting
Not Applicable

Neuromuscular Electrical Stimulation in a Patient on Invasive Mechanical Ventilation (MOVCARE)

Mechanical VentilationCritical IllnessNeuromuscular Electrical Stimulation (NMES)+2 more
Hospital Moinhos de Vento150 enrolled1 locationNCT07188350
Recruiting

Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients

Acute Respiratory FailureCritical Illness
The Institute of Molecular and Translational Medicine, Czech Republic200 enrolled2 locationsNCT06189924
Recruiting
Not Applicable

PICU-related Sleep and Circadian Dysregulation Pilot Study

Sleep DisturbanceCritical IllnessChildren, Only+1 more
State University of New York at Buffalo30 enrolled1 locationNCT06505447
Recruiting

Assessing Fluid-responsiveness Using Non-invasive Hybrid Diffuse Optics on Peripheral Muscle

Critical Illness
Corporacion Parc Tauli200 enrolled1 locationNCT07298720
Recruiting

Treatment Strategy of Human Gamma Globulin on the Therapy for Intensively Ill Children With Inflammatory Storm

Critical IllnessSepsis, Severe
Children's Hospital of Fudan University200 enrolled2 locationsNCT04850456
Recruiting

A Multi-Center Data System and Collaborative Network in China for Severe Infection and Sepsis Children

Critical Illness
Children's Hospital of Fudan University5,000 enrolled1 locationNCT04955210
Recruiting

Critical Illness Weakness Outside the Intensive Care Unit.

Critical Illness MyopathyCritical Illness PolyneuropathyCritical Illness Polyneuromyopathy
Istituto Clinico Humanitas300 enrolled1 locationNCT07478367
Recruiting

Transcutaneous pO₂ Monitoring in PICU

Pediatric Critical Illness
Istanbul Medeniyet University50 enrolled1 locationNCT07478380
Recruiting
Not Applicable

The Effect of Continuous Versus Intermittent Enteral Nutrition on Metabolic Outcomes in Critically Ill Patients

Critical Illness
Gelderse Vallei Hospital124 enrolled5 locationsNCT07173504