RecruitingPhase 2NCT04044534
Intranasal Insulin for Posttraumatic Stress Disorder
Intranasal Insulin for Treating Posttraumatic Stress Disorder
Sponsor
VA Connecticut Healthcare System
Enrollment
20 participants
Start Date
Oct 31, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
To evaluate if intranasal insulin is effective in reducing PTSD symptoms.
Eligibility
Min Age: 21 YearsMax Age: 65 Years
Inclusion Criteria3
- Male or female, 21-65 years old
- Current PTSD
- Able to provide written informed consent
Exclusion Criteria11
- Unstable medical condition, clinically determined by a physician
- Diabetes requiring insulin or oral hypoglycemic agents
- Moderate-severe traumatic brain injury
- Current psychotic disorder, bipolar disorder, cognitive disorder in the past 12 months
- Current substance use disorders (except alcohol, tobacco, or cannabis) in the past 3 months
- Changes in doses of psychotropic medications in the past 4 weeks
- Initiation of individual therapy or counseling in the past 4 weeks
- Imminent suicidal or homicidal risk
- Contraindication to Insulin
- History of claustrophobia
- Presence of cardiac pacemaker or other electronic device or ferromagnetic metal foreign bodies in vulnerable positions as assessed by a standard pre-MRI safety screening questionnaire
Interventions
DRUGIntranasal insulin
Subjects in this arm will receive intranasal insulin (80 IU per day).
DRUGPlacebo
Subjects in this arm will receive placebo.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04044534
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