Intranasal Insulin for Posttraumatic Stress Disorder

This trial tests whether intranasal insulin — insulin delivered as a nasal spray directly to the brain — can reduce symptoms of post-traumatic stress disorder (PTSD). Insulin in the brain affects memory and stress pathways, and researchers think it might help "dampen" traumatic memories. **You may be eligible if...** - You have been diagnosed with PTSD - You are 18 or older - You are not currently taking insulin for diabetes - You are willing to use a nasal spray device during the study **You may NOT be eligible if...** - You have type 1 diabetes or insulin-dependent type 2 diabetes - You have a history of low blood sugar episodes (hypoglycemia) - You are pregnant or breastfeeding - You have significant nasal or sinus problems that would prevent nasal spray use - You have active psychosis or certain other psychiatric conditions Talk to your doctor to see if this trial is right for you.