RecruitingNot ApplicableNCT06096740

Psychotherapy Effects on Reward Processing in PTSD

The Effects of Trauma-focused Psychotherapy on Reward Circuitry Function and Information Encoding


Sponsor

University of Texas at Austin

Enrollment

120 participants

Start Date

Jun 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to identify how trauma-focused psychotherapy changes the function of brain circuitry in posttraumatic stress disorder (PTSD) and how this mediates improvements in the diminished ability to experience positive emotions following a traumatic or extremely stressful life event. In this instance, the investigators will be using cognitive processing therapy (CPT), a widely-utilized and evidence-based treatment for PTSD.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is using brain imaging (fMRI) to examine how different psychotherapies affect the brain's reward processing in people with PTSD. Many people with PTSD struggle to feel pleasure or motivation, and researchers want to understand how therapy changes these brain patterns to develop more effective treatments. **You may be eligible if...** - You have a confirmed, current PTSD diagnosis (present for at least 3 months) based on clinical interview - English is your primary language - You are able and willing to undergo fMRI brain scans - You are willing to participate in multiple assessments and potentially be in a delayed treatment group **You may NOT be eligible if...** - You have a history of psychosis or bipolar disorder - You have had active substance dependence in the past 6 months - You are currently taking regular psychiatric medications that could affect brain imaging results - You have metal implants or other contraindications to MRI Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

BEHAVIORALCognitive Processing Therapy

Cognitive processing therapy is a widely-utilized, empirically-supported treatment developed for PTSD. It is based on a cognitive theory of trauma which emphasizes the impact of trauma on belief systems and the development of "stuck points", which are unhealthy, unrealistic, and maladaptive ways of thinking that serve to maintain unhealthy beliefs and reinforce PTSD symptoms.


Locations(1)

Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600

Austin, Texas, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06096740


Related Trials