RecruitingNot ApplicableNCT04061135

Neurophysiological, Behavioral, and Cognitive Networks in Movement Disorders

Sponsor

University of Alabama at Birmingham

Enrollment

90 participants

Start Date

Sep 1, 2019

Study Type

INTERVENTIONAL

Conditions

Movement Disorders

Summary

The purpose of this study is to investigate the brain activity associated with motor and non-motor symptoms of movement disorders, including Parkinson's disease (PD) and essential tremor. These movement disorders commonly have significant non-motor features, such as depression, cognitive and memory impairment, decreased attention, speech and language disturbances, and slower processing speeds. The investigators are interested in the brain activity associated with these motor and non-motor symptoms, and propose to investigate changes in brain activity while the investigators perform recordings of the surface and deep structures of the brain, in addition to the typical recordings the investigators perform, during routine deep brain stimulation (DBS) surgery.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how deep brain stimulation (DBS) — a surgical treatment that implants electrodes in the brain — affects movement, thinking, and brain activity in people with movement disorders. Researchers hope to better understand how the brain works in these patients to improve treatment. **You may be eligible if...** - You have been diagnosed with Parkinson's disease or Essential Tremor (a movement disorder causing uncontrollable shaking) - A medical team has agreed you are a good candidate for DBS surgery - You are at least 18 years old - You have already tried medication-based treatments without adequate improvement - You are willing and able to participate in study activities **You may NOT be eligible if...** - You cannot give informed consent - You are pregnant or have other health conditions that make surgery too risky - DBS surgery is not medically appropriate for your specific condition - You are unable to participate in study-related tasks Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREResponse Inhibition and Deep Brain Stimulation in Parkinson's disease

After creation of the burr hole and prior to DBS electrode placement, 1-2 subdural strip electrodes will be placed anteriorly or posteriorly from the cranial opening. These electrodes are routinely placed using this technique for seizure mapping, with arrays of electrodes (up to 6) being placed around the perimeter of the opening.14 Subdural strips vary in length and contact size (e.g., the 6-contact Ad-Tech strip), and are currently placed predominantly for studies of sensorimotor function,13 including at our institution (IRB-140327003). Placement over prefrontal areas is performed at other institutions.11-13 The DBS surgery will then proceed according to routine practice, and following lead placement in the optimal desired location, the research task paradigm will begin.