A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications

This registry is collecting follow-up data on patients who undergo a procedure called focused ultrasound pallidotomy (using the Exablate 4000 device) for advanced Parkinson's disease. The procedure uses sound waves to precisely destroy a small area of the brain (the globus pallidus) that causes tremors, stiffness, and movement complications when medications stop working well. This is a post-market registry — the device is already approved — and the study is tracking long-term outcomes. **You may be eligible if:** - You are 30 years or older - You have idiopathic (typical) Parkinson's disease with significant motor complications (tremors, dyskinesia) not adequately controlled by medication - Your doctor has already planned or is performing an Exablate focused ultrasound procedure as standard care - You are willing and able to attend all follow-up visits **You may NOT be eligible if:** - You are unwilling to participate for the full duration of the registry Talk to your doctor to see if this trial is right for you.