RecruitingPhase 3NCT04063527

Phase III Trial of Stage I Ovarian Cancer After Surgery

Randomized Phase III Trial of the Need for Adjuvant Chemotherapy in Stage I Epithelial Ovarian Cancer After Comprehensive Staging Surgery

Sponsor

Japanese Gynecologic Oncology Group

Enrollment

360 participants

Start Date

Jul 20, 2012

Study Type

INTERVENTIONAL

Conditions

Epithelial Ovarian Cancer

Summary

To compare the Overall survival of adjuvant chemotherapy versus observation in stage I epithelial ovarian cancer after comprehensive staging surgery

Eligibility

Sex: FEMALEMin Age: 20 Years

Plain Language Summary

Simplified for easier understanding

This Phase III clinical trial is studying the best treatment approach for early-stage ovarian cancer after surgery. It compares different chemotherapy regimens to find which is most effective at preventing cancer from coming back. **You may be eligible if...** - You have been diagnosed with early-stage epithelial ovarian cancer (Stage Ia Grade 2/3, Ib Grade 2/3, or Ic) - You have had comprehensive staging surgery including removal of the uterus, ovaries, fallopian tubes, and tissue samples from multiple areas - Your diagnosis has been confirmed by pathology **You may NOT be eligible if...** - You have a more advanced stage of ovarian cancer that does not fit the study criteria - You did not have adequate staging surgery - You do not meet the study's specific surgical and histological requirements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGadjuvant chemotherapy

combination of paclitaxel and carboplatin

Locations(103)

Aichi Medical University Hospital

Nagakute-shi, Aichi-ken, Japan

Tosei General Hospital

Seto-shi, Aichi-ken, Japan

Fujita Health University Hospital

Toyoake-shi, Aichi-ken, Japan

Hirosaki University School of Medicine & Hospital

Hirosaki-shi, Aomori, Japan

The Jikei University School of Medicine Kashiwa Hospital

Kashiwa-shi, Chiba, Japan

National Cancer Center Hospital East

Kashiwa-shi, Chiba, Japan

Ehime University Hospital

Onsen-gun, Ehime, Japan

Kyusyu Medical Center

Fukuoka, Fukuoka, Japan

Kyusyu Cancer Center

Fukuoka, Fukuoka, Japan

Kyushu University Hospital

Fukuoka, Fukuoka, Japan

Kurume University Hospital

Kurume-shi, Fukuoka, Japan

Gifu University Hospital

Gifu, Gifu, Japan

Gunma University Hospital

Maebashi, Gunma, Japan

Gunma Prefectural Cancer Center

Ōta, Gunma, Japan

JA Hiroshima General Hospital

Hatsukaichi-shi, Hiroshima, Japan

Hiroshima City Hiroshima Citizens Hospital

Hiroshima, Hiroshima, Japan

Hiroshima Prefectural Hospital

Hiroshima, Hiroshima, Japan

Miyoshi Central Hospital

Miyoshi-shi, Hiroshima, Japan

Hospital Hakodate Hokkaido

Hakodate-shi, Hokkaido, Japan

JA Sapporo-Kosei general Hospital

Sapporo, Hokkaido, Japan

Hokkaido University Hospita

Sapporo, Hokkaido, Japan

Hyogo Cancer Center

Akashi-shi, Hyōgo, Japan

Kansai Rosai Hospital

Amagasaki-shi, Hyōgo, Japan

Japanese Red Cross Society Himeji Hospital

Himeji-shi, Hyōgo, Japan

University of Tsukuba Hospital

Tsukuba, Ibaraki, Japan

Iwate Medical University Hospital

Morioka, Iwate, Japan

Kagoshima University Medical And Dental Hospital

Kagoshima, Kagoshima-ken, Japan

Kagoshima City Hospital

Kagoshima, Kagoshima-ken, Japan

Tokai University Hospital

Isehara-shi, Kanagawa, Japan

St.Marianna University School of Medicine Hospital

Kawasaki-shi, Kanagawa, Japan

Kitasato University Hospital

Sagamihara, Kanagawa, Japan

Yokohama City University Hospital

Yokohama, Kanagawa, Japan

Yokohama Minami Kyosai Hospital

Yokohama, Kanagawa, Japan

Yokohama Municipal Citizen's Hospital

Yokohama, Kanagawa, Japan

Kanagawa Cancer Center

Yokohama, Kanagawa, Japan

Kobe City Medical Center General Hospital

Kobe, Kobe, Japan

Kumamoto University Hospital

Kumamoto, Kumamoto, Japan

Japanese Red Cross Kyoto Daiichi Hospital

Kyoto, Kyoto, Japan

Ise Red Cross Hospital

Ise-shi, Mie-ken, Japan

JA Matsuzaka Central Hospital

Matsuzaka, Mie-ken, Japan

Mie University Hospital

Tsu, Mie-ken, Japan

Tohoku University Hospital

Sendai, Miyagi, Japan

Shinshu University Hospital

Matsumoto-shi, Nagano, Japan

Nagasaki University Hospital

Nagasaki, Nagasaki, Japan

Aichi Cancer Center

Nagoya, Nagoya, Japan

Nara Prefecture General Medical Center

Nara, Nara, Japan

Niigata University Medical and Dental Hospital

Niigata, Niigata, Japan

Niigata Cancer Center Hospital

Niigata, Niigata, Japan

Oita University Hospital

Yufu, Oita Prefecture, Japan

Hospital University of the Ryukyus

Nakagami-gun, Okinawa, Japan

Tomishiro Central Hospital

Tomishiro-shi, Okinawa, Japan

Okinawa Prefectural Chubu Hospital

Uruma, Okinawa, Japan

Kaizuka City Hospital

Kaizuka, Osaka, Japan

Osaka International Cancer Center

Osaka, Osaka, Japan

Osaka City University Hospital

Osaka, Osaka, Japan

Kindai University Hospital

Ōsaka-sayama-shi, Osaka, Japan

Sakai City Medical Center

Sakai, Osaka, Japan

Osaka University Hospital

Suita-shi, Osaka, Japan

Osaka Medical College Hospital

Takatsuki-shi, Osaka, Japan

Saitama Medical University International Medical Center

Hidaka-shi, Saitama, Japan

Koshigaya Municipal Hospital

Koshigaya-shi, Saitama, Japan

Dokkyo Medical University Saitama Medical Center

Koshigaya-shi, Saitama, Japan

Saitama Cancer Center

Shinden, Saitama, Japan

National Defense Medical College Hospital

Tokorozawa-shi, Saitama, Japan

Saitama National Hospital

Wako, Saitama, Japan

Sapporo Medical University Hospital

Sapporo, Sapporo, Japan

Shikoku Cancer Center

Matsuyama, Shikoku, Japan

Shimane University Hospital

Izumo, Shimane, Japan

Shizuoka Cancer Center

Nagaizumi-chō, Shizuoka, Japan

Japanese Red Cross Shizuoka Hospital

Shizuoka, Shizuoka, Japan

Dokkyo Medical University Hospital

Mibu, Tochgi, Japan

Jichi Medical University Hospital

Shimotsuke-shi, Tochigi, Japan

Tokushima University Hospital

Tokushima, Tokushima, Japan

Tokyo Women's Medical University Medical Center East

Arakawa City, Tokyo, Japan

Tokyo Medical And Dental University University Hospital of Medicine

Bunkyō-Ku, Tokyo, Japan

Nippon Medical School Hospital

Bunkyō-Ku, Tokyo, Japan

The University of Tokyo Hospital

Bunkyō-Ku, Tokyo, Japan

Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital

Bunkyō-Ku, Tokyo, Japan

Sasaki Faundation Kyoundo Hospital

Chiyoda City, Tokyo, Japan

Tokyo Metropolitan Tama Medical Center

Fuchu-shi, Tokyo, Japan

The Jikei University Katsushika Medical Center

Katsushika-ku, Tokyo, Japan

The Jikei University Daisan Hospital

Komae-shi, Tokyo, Japan

The Cancer Institute Hospital

Koto-Ku, Tokyo, Japan

Toho University Ohashi Medical Center

Meguro-ku, Tokyo, Japan

The Jikei University Hospital

Minato-ku, Tokyo, Japan

Keio University Hospital

Shinjuku-ku, Tokyo, Japan

Tokyo Women's Medical University Hospital

Shinjuku-Ku, Tokyo, Japan

Kosei General Hospital

Suginami, Tokyo, Japan

Tachikawa Hospital

Tachikawa-shi, Tokyo, Japan

Tottori Prefectural Central Hospital

Tottori-shi, Tottori, Japan

Tottori University Hospital

Yonago-shi, Tottori, Japan

Yamagata University Hospital

Yamagata, Yamagata, Japan

Tokuyama Central Hospital

Shunan-shi, Yamaguchi, Japan

Yamaguchi Red Cross Hospital

Yamaguchi, Yamaguchi, Japan

Nagano Municipal Hospital

Nagano, Japan

Saiseikai Nagasaki Hospital

Nagasaki, Japan

Saga University Hospital

Saga, Japan

Jichi Medical University Saitama Medical Center

Saitama, Japan

National Cancer Center

Ilsandong, Goyang, South Korea

Gachon University Gil Medical Center

Namdong, Incheon, South Korea

Seoul ST' Mary's Hospital

Seocho, Seoul, South Korea

Kangbuk Samsung Hospital

Seoul, South Korea

Severance Hospital

Seoul, South Korea

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