Vivax Malaria Human Infection Studies in Thailand
A Clinical Study to Assess the Feasibility of a Controlled Human Plasmodium Vivax Malaria Infection Model Through Sporozoite Infection in Thai Adults
University of Oxford
6 participants
Oct 5, 2020
INTERVENTIONAL
Conditions
Summary
This study is a human challenge study to assess the feasibility and safety of controlled human malaria infection (via P. vivax sporozites) in healthy volunteers, and to develop a bank of P. vivax-infected blood for use in future controlled human P. vivax malaria infection studies. Additional objectives are to obtain data on host immune response to P. vivax infection and pre-treatment gametocytaemia. This study is funded by the UK Wellcome Trust. The grant reference number are Oxford/MORU: 212336/Z/18/Z and 212336/Z/18/A, and Mahidol University: 212336/A/18/Z and 212336/A/18/A.
Eligibility
Plain Language Summary
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Interventions
Successful feeding of 5 infected P. vivax mosquitoes
Locations(1)
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NCT04083508