RecruitingNot ApplicableNCT07257965

Clinical Study to Assess Minimum Mosquito Bites for P. Vivax Infection in Thai Adults

A Clinical Study to Assess the Minimum Number of Infective Mosquito Bites to Achieve Malaria Infection in Healthy Thai Adults Using Controlled Human Plasmodium Vivax Infected Mosquito Challenge

Sponsor

University of Oxford

Enrollment

24 participants

Start Date

Feb 2, 2026

Study Type

INTERVENTIONAL

Conditions

Plasmodium vivax infection

Summary

This study is a human challenge study to assess the minimum infective mosquito bite dose in a controlled human malaria Infection (via P. vivax sporozites) in healthy volunteers. The results will inform the development of a P. vivax mosquito-delivered CHMI trial platform, supporting safer and more accurate vaccine efficacy assessments. Conducting the trial in individuals genetically and immunologically similar to the target population will also enhance the relevance of findings to real-world endemic settings. This study is funded by the UK Wellcome Trust. The grant reference number are Oxford/MORU: 212336/Z/18/Z and 212336/Z/18/A, and Mahidol University: 212336/A/18/Z and 212336/A/18/A.

Eligibility

Min Age: 20 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study is testing how many bites from a Plasmodium vivax-infected mosquito are needed to reliably cause a malaria infection in healthy Thai adults, as part of developing a controlled human malaria infection (CHMI) research platform for vaccine testing. Researchers will start with a single mosquito bite and may increase the number based on results, aiming to find the minimum dose that consistently produces infection. You may be eligible if you are a healthy Thai adult aged 20 to 55 with no history of malaria, normal blood cell counts, and are willing to be hospitalized for monitoring and treated with antimalarials if infected. Participation involves being bitten by an infected mosquito under controlled conditions, close hospital monitoring, and one year of follow-up after treatment. This summary was prepared using AI to help patients understand this research.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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