Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection Syndrome

This study compares two treatments for people who develop bowel problems after surgery for rectal cancer — a condition called Low Anterior Resection Syndrome (LARS). Symptoms can include unpredictable bowel movements, urgency, and incontinence. The two treatments being compared are transanal irrigation (flushing out the bowel with water) and glycerol suppositories. **You may be eligible if...** - You had surgery for rectal cancer (low anterior resection) at least 3 months ago - You have significant bowel problems (LARS score above 29) that have not improved with initial treatment - You are 18 or older **You may NOT be eligible if...** - You have used transanal irrigation before - You have a narrowing at the surgical join (anastomotic stenosis) or a history of leakage at the join - Your cancer has returned or spread - You have another bowel condition like inflammatory bowel disease - You are currently receiving cancer treatment - You have had radiation to your pelvis after surgery - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.