Low Anterior Resection Syndrome Clinical Trials

11 recruiting

Low Anterior Resection Syndrome Trials at a Glance

16 actively recruiting trials for low anterior resection syndrome are listed on ClinicalTrialsFinder across 6 cities in 10 countries. The largest study group is Not Applicable with 11 trials, with the heaviest enrollment activity in Seoul, Leuven, and Guangzhou. Lead sponsors running low anterior resection syndrome studies include Seoul National University Hospital, KU Leuven, and Innovacion en Cirugía Vigo.

Browse low anterior resection syndrome trials by phase

Treatments under study

About Low Anterior Resection Syndrome Clinical Trials

Looking for clinical trials for Low Anterior Resection Syndrome? There are currently 11 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Low Anterior Resection Syndrome trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Low Anterior Resection Syndrome clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 116 of 16 trials

Recruiting
Not Applicable

A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer Patients

Rectal CarcinomaLow Anterior Resection Syndrome
Ohio State University Comprehensive Cancer Center80 enrolled1 locationNCT06424522
Recruiting
Not Applicable

Personalized Care Pathways for Bowel Symptoms in Rectal Cancer patients_development of E-diary

Rectal CancerLARS - Low Anterior Resection Syndrome
KU Leuven158 enrolled1 locationNCT06274190
Recruiting
Phase 2Phase 3

Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a Single-Center, Prospective Randomized Controlled Trial.

Rectal CancerLow Anterior Resection Syndrome
Pei-Rong Ding160 enrolled1 locationNCT07537998
Recruiting
Not Applicable

Personalized Care Pathways for Bowel Symptoms in Rectal Cancer Patients_contributing Factors (Treatable)

Rectal CancerLARS - Low Anterior Resection SyndromeActive Surveillance
KU Leuven150 enrolled1 locationNCT06914245
Recruiting
Not Applicable

ProLARS Trial: Prospective Longitudinal Follow-up of Low Anterior Resection Syndrome (LARS) and COREFO Score After Rectum Surgery in Patients Undergoing Upfront Surgery or Different Neo-adjuvant Treatment Regimens

Rectal AdenocarcinomaLARS - Low Anterior Resection SyndromeLow Anterior Resection+2 more
University Hospital, Antwerp100 enrolled1 locationNCT07339904
Recruiting
Not Applicable

Comparison of Postoperative Anal Function Between Parks and Bacon Techniques in Low Rectal Cancer

Quality of LifeRectal NeoplasmsLow Anterior Resection Syndrome+1 more
Sixth Affiliated Hospital, Sun Yat-sen University256 enrolled1 locationNCT05943444
Recruiting

A Randomised Clinical Investigation to Assess Efficacy of Low Volume Transanal Irrigation by Qufora® IrriSedo MiniGo Versus Conservative Treatment for Low Anterior Resection Syndrome Patients

Rectal CancerLARS - Low Anterior Resection SyndromeGastroenterology
Qufora A/S78 enrolled9 locationsNCT06923150
Recruiting
Not Applicable

Paula Method of Exercises in Patients With LARS Syndrome:Randomized Controlled Trial

Low Anterior Resection Syndrome
Hadassah Medical Organization62 enrolled2 locationsNCT05682157
Recruiting
Phase 2Phase 3

Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer.

Radiotherapy Side EffectNeoadjuvant TherapyChemotherapy+8 more
National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos400 enrolled1 locationNCT06758830
Recruiting
Not Applicable

The Effects of Colorectal Prehabilitation Via Reinfusion or Retention Enema of Ileal Contents Filtrate on the Defecation Functions for the LAR Patients With Ileostomy Before Stoma Closure

Low Anterior Resection Syndrome
The Affiliated Hospital of Qingdao University154 enrolled1 locationNCT06569966
Recruiting
Not Applicable

Effectiveness of Pelvic Floor Exercise to Prevent LARS (Low Anterior Resection Syndrome)

Rectal CancerPreventionPelvic Floor Disorders+2 more
F. D. Roosevelt University Hospital50 enrolled1 locationNCT06519006
Recruiting
Not Applicable

The Safety and Efficacy of Transanal Irrigation in Patients With Sleep Disturbance From Low Anterior Resection Syndrome After Rectal Cancer Surgery (TraLARS)

Rectal CancerInsomniaLow Anterior Resection Syndrome+1 more
Seoul National University Hospital52 enrolled1 locationNCT06222255
Recruiting
Not Applicable

Impact of Early Postoperative Treatment With Posterior Tibial Nerve Stimulation on the Incidence and Duration of Low Anterior Rectal Resection Syndrome

Low Anterior Resection SyndromeLow Anterior ResectionRectal Disorders
Innovacion en Cirugía Vigo114 enrolled1 locationNCT05368168
Recruiting

Assessment of Quality of Life After Low Anterior Resection During Cytoreductive Surgery for Advanced Ovarian Cancer

Ovarian CancerQuality of LifeLow Anterior Resection Syndrome
Seoul National University Hospital108 enrolled1 locationNCT05431530
Recruiting
Phase 3

Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection Syndrome

Rectal CancerLow Anterior Resection Syndrome
University of Aarhus114 enrolled1 locationNCT04087421
Recruiting
Not Applicable

5-HT3 Receptor Antagonist (Ramosetron) vs Loperamide for the Treatment of Low Anterior Resection Syndrome(RALARS)

LARS - Low Anterior Resection Syndrome
Seoul National University Hospital212 enrolled1 locationNCT05577845