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RecruitingNCT04095195

Registry of Subjects at Risk of Pancreatic Cancer

Italian Registry of Families At Risk of Pancreatic Cancer

Sponsor

Associazione Italiana per lo Studio del Pancreas

Enrollment

1,000 participants

Start Date

Aug 20, 2019

Study Type

OBSERVATIONAL

Conditions

BRCA1 MutationBRCA2 MutationLynch SyndromeFamilial Pancreatic CancerFAMMM - Familial Atypical Mole Malignant Melanoma SyndromeHereditary PancreatitisPeutz-Jeghers Syndrome

Summary

IRFARPC is a multicenter national registry designed to study the diagnosis and predisposing factors of subjects with an inherited increased risk for pancreatic cancer.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria9

  • individuals with at least two relatives suffering from pancreatic cancer, with at least 1 first-degree and until the third-degree
  • subjects with known genetic mutation of BRCA2, BRCA1, p16, PALB2 with at least 1 first- or 2nd-degree relative suffering from pancreatic cancer
  • subjects suffering from FAMMM Syndrome
  • subjects suffering from Peutz-Jeghers Syndrome
  • subjects suffering from PRSS-1- or CFTR- or SPINK-1- related pancreatitis
  • subjects suffering from Lynch syndrome with at least 1 first- or 2nd-degree relative suffering from pancreatic cancer
  • years or 10 years younger than the youngest index case of pancreatic cancer in the family for familial cases
  • years or 5 years younger than the youngest index case of pancreatic cancer for subjects suffering from hereditary/genetic pancreatitis, Lynch syndrome, or carrying a known BRCA 1/2, PALB2, p16 genetic mutation with familiarity for pancreatic cancer
  • years for subjects suffering from FAMMM, Peutz-Jeghers syndrome

Exclusion Criteria1

  • \- pregnancy

Interventions

RADIATIONMRCP

Subjects fulfilling the "radiological follow-up criteria" will be submitted to MRCP or EUS according to the pancreatologist's prescription

PROCEDUREEndoultrasonography

Subjects fulfilling the "radiological follow-up criteria" will be submitted to MRCP or EUS according to the pancreatologist's prescription

Locations(4)

Istituto Clinico Humanitas

Rozzano, Milan, Italy

Ospedale Pederzoli

Peschiera del Garda, Verona, Italy

San Raffele Vita Salute University Hospital

Milan, Italy

Chirurgia Generale e del Pancreas

Verona, Italy

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